1-methyl-2-<3-(methylthio)propyl>imidazole | 93530-04-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-methyl-2-<3-(methylthio)propyl>imidazole
• 英文别名: 1-methyl-2-methylthiopropylimidazole；1H-Imidazole, 1-methyl-2-[3-(methylthio)propyl]-；1-methyl-2-(3-methylsulfanylpropyl)imidazole
• CAS: 93530-04-2
• 化学式: C₈H₁₄N₂S
• 分子量: 170.279
• InChiKey: IYXRGRHLTSUILE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  43.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methyl-2-<3-(methylthio)propyl>imidazole 在 potassium triiodide 、 potassium iodide 作用下， 生成 2-(3-Methanesulfinyl-propyl)-1-methyl-1H-imidazole
  参考文献：
  名称：

  Neighboring-group participation in organic redox reactions. 10. The kinetic and mechanistic effects of imidazole and benzimidazole nitrogen on thioether oxidations

  摘要：

  DOI：

  10.1021/jo00201a002
• 作为产物：
  描述：

  N-甲基咪唑 、 3-iodopropyl methyl sulfide 在 正丁基锂 作用下， 生成 1-methyl-2-<3-(methylthio)propyl>imidazole
  参考文献：
  名称：

  Neighboring-group participation in organic redox reactions. 10. The kinetic and mechanistic effects of imidazole and benzimidazole nitrogen on thioether oxidations

  摘要：

  DOI：

  10.1021/jo00201a002

文献信息

• [EN] PLATINUM(II) COMPLEXES, PREPARATION AND USE<br/>[FR] COMPLEXES DE PLATINE-II, PREPARATION ET UTILISATION
  申请人：PLATCO TECHNOLOGIES PROPRIETAR

  公开号：WO2005051966A1

  公开（公告）日：2005-06-09

  This invention relates to a method for the preparation of platinum(II) complexes, in particular dicarboxylatoplatinum(II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a bis-dicarboxylatoplatinate(II) species with a suitable neutral bidentate ligand to form a neutral dicarboxylatoplatinum(II) complex and, if necessary, recrystallising the product to form a pure dicarboxylatoplatinum(II) complex containing a neutral bidentate ligand. The invention also relates to a method for producing a bis-dicarboxylatoplatinate(II) species, and to new platinum(II) complexes that can be made by the method of the invention.

  本发明涉及一种制备铂（II）配合物的方法，特别是含有中性双齿配体（如奥沙利铂）的二羧基铂（II）配合物。该方法包括将双羧基铂酸盐（II）物种与适当的中性双齿配体反应，形成中性二羧基铂（II）配合物，并在必要时重结晶产物，以形成含有中性双齿配体的纯二羧基铂（II）配合物。本发明还涉及一种制备双羧基铂酸盐（II）物种的方法，以及可以通过本发明方法制备的新铂（II）配合物。
• Platinum (IV) Complexes
  申请人：Du Preez Jan Gysbert Hermanus

  公开号：US20110021483A1

  公开（公告）日：2011-01-27

  Provided are nitroplatinum(IV) complexes containing a bidentate dicarboxylate ligand (e.g., oxalate) which maybe useful treating various forms of proliferative diseases, such as cancer. In some instances the platinum(IV) complexes are relatively stable and may be suitable for oral administration. Also provided are methods of treatment, as well as kits and unit dosages.
• BENZAMIDE AND NICOTINAMIDE COMPOUNDS AND METHODS OF USING SAME
  申请人：OncoTartis Inc.

  公开号：US20190031658A1

  公开（公告）日：2019-01-31

  Benzamide and nicotinamide compounds and uses of the compounds. The compounds can be used to treat, for example, cancers such hematopoietic cancers (e.g., leukemia).