5,6-dihydroxy-3-methylquinolin-2(1H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5,6-dihydroxy-3-methylquinolin-2(1H)-one
• 英文别名: 5,6-dihydroxy-3-methyl-1H-quinolin-2-one
• 化学式: C₁₀H₉NO₃
• 分子量: 191.18
• InChiKey: IYHQVDIUZANYNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  73.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-methyl-5,6-dihydroquinoline-2,5,6-triol 、 nicotinamide adenine dinucleotide 生成 5,6-dihydroxy-3-methylquinolin-2(1H)-one 、 氢(+1)阳离子 、 NADH
  参考文献：
  名称：

  Microbial Metabolism of Quinoline and Related Compounds. XVII. Degradation of 3-Methylquinoline by Comamonas testosteroni 63

  摘要：

  A bacterial strain which utilizes 3-methyl-quinoline as sole source of carbon, nitrogen and energy was isolated from activated sludge. On the basis of its morphological and physiological characteristics, this isolate was classified as Comamonas testosteroni. Four metabolites of 3-methylquinoline degradation were isolated from the culture supernatant and identified as 3-methyl-2-oxo-1,2-dihydroquinoline, 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline, 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline and 2,5,6-trihydroxy-3-methylpyridine. Based on these results, a degradation pathway for 3-methylquinoline is proposed.

  DOI：

  10.1515/bchm3.1993.374.1-6.175

文献信息

• Microbial Metabolism of Quinoline and Related Compounds. XVII. Degradation of 3-Methylquinoline by Comamonas testosteroni 63
  作者：Susanne SCHACH、Gerhild SCHWARZ、Susanne FETZNER、FRANZ LINGENS

  DOI：10.1515/bchm3.1993.374.1-6.175

  日期：1993.1

  A bacterial strain which utilizes 3-methyl-quinoline as sole source of carbon, nitrogen and energy was isolated from activated sludge. On the basis of its morphological and physiological characteristics, this isolate was classified as Comamonas testosteroni. Four metabolites of 3-methylquinoline degradation were isolated from the culture supernatant and identified as 3-methyl-2-oxo-1,2-dihydroquinoline, 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline, 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline and 2,5,6-trihydroxy-3-methylpyridine. Based on these results, a degradation pathway for 3-methylquinoline is proposed.