4,5-Bis(thien-2-yl)-1,2,3-thiadiazole | 94843-24-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4,5-Bis(thien-2-yl)-1,2,3-thiadiazole
• 英文别名: 4,5-Bis(2-thienyl)-1,2,3-thiadiazole；4,5-dithiophen-2-ylthiadiazole
• CAS: 94843-24-0
• 化学式: C₁₀H₆N₂S₃
• 分子量: 250.369
• InChiKey: UYJVOBUKQQNVCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  111
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,2-bis(2-thienyl)ethanone 在 氯化亚砜 、 对甲苯磺酸 、 肼基甲酸乙酯 作用下， 生成 4,5-Bis(thien-2-yl)-1,2,3-thiadiazole
  参考文献：
  名称：

  Synthesis and platelet aggregation inhibitory activity of 4,5-bis(substituted)-1,2,3-thiadiazoles

  摘要：

  Routine screening of compounds for inhibition of collagen-induced platelet aggregation in vitro revealed 4,5-bis-(4-methoxyphenyl)-1,2,3-thiadiazole (2) was active and it represents the first example of a 1,2,3-thiadiazole with possible antithrombotic activity. In order to develop a structure-activity relationship for this heterocycle, a number of new 4(5)-mono- and -disubstituted 1,2,3-thiadiazoles were synthesized. These were tested in our screen and a number of additional active compounds were found. The most active compounds (2, 5a, 5b, and 6c) were those in which the heterocycle was substituted with benzene rings possessing para electron-donating groups.

  DOI：

  10.1021/jm00382a009

文献信息

• 1,2,3-thiadiazole compounds, compositions and method of anti-thrombotic
  申请人：The Upjohn Company

  公开号：US05098918A1

  公开（公告）日：1992-03-24

  Novel 1,2,3-thiadiazole compounds, new and old 1,2,3-thiadiazole compositions and method of anti-thrombotic treatment are systemically administered to a human or animal.

  小说1,2,3-噻二唑化合物，新旧1,2,3-噻二唑组合物和抗血栓治疗方法被系统地用于人类或动物。
• Dithiophenethiadiazole semiconductors and related devices
  申请人：Flexterra, Inc.

  公开号：US10355213B2

  公开（公告）日：2019-07-16

  The present invention relates to new semiconducting compounds having at least one optionally substituted dithieno[1,2,3]thiadiazole moiety. The compounds disclosed herein can exhibit high carrier mobility and/or efficient light absorption/emission characteristics, and can possess certain processing advantages such as solution-processability and/or good stability at ambient conditions.

  本发明涉及具有至少一个任选取代的二噻吩并[1,2,3]噻二唑分子的新型半导体化合物。本发明公开的化合物可表现出高载流子迁移率和/或高效光吸收/发射特性，并具有某些加工优势，如溶液加工性和/或在环境条件下的良好稳定性。
• THOMAS, E. W.;NISHIZAWA, E. E.;ZIMMERMANN, D. C.;WILLIAMS, D. J., J. MED. CHEM., 1985, 28, N 4, 442-446
  作者：THOMAS, E. W.、NISHIZAWA, E. E.、ZIMMERMANN, D. C.、WILLIAMS, D. J.

  DOI：——

  日期：——
• DITHIOPHENETHIADIAZOLE SEMICONDUCTORS AND RELATED DEVICES
  申请人：Flexterra, Inc.

  公开号：US20180323375A1

  公开（公告）日：2018-11-08

  The present invention relates to new semiconducting compounds having at least one optionally substituted dithieno[1,2,3]thiadiazole moiety. The compounds disclosed herein can exhibit high carrier mobility and/or efficient light absorption/emission characteristics, and can possess certain processing advantages such as solution-processability and/or good stability at ambient conditions.