4-hydroxy-1-(2-[isopropyl(methyl)amino]quinolin-6-yl)pyridine-2(1H)-one | 929192-64-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-hydroxy-1-(2-[isopropyl(methyl)amino]quinolin-6-yl)pyridine-2(1H)-one
• 英文别名: 4-Hydroxy-1-{2-[isopropyl(methyl)amino]quinolin-6-yl}pyridin-2(1H)-one；4-Hydroxy-1-[2-[methyl(propan-2-yl)amino]quinolin-6-yl]pyridin-2-one
• CAS: 929192-64-3
• 化学式: C₁₈H₁₉N₃O₂
• 分子量: 309.368
• InChiKey: RLAYKCQBAJYNCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  56.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N₂-isopropyl-N₂-methylquinoline-2,6-diamine 、 4-羟基吡喃-2-酮 以 正丁醇 为溶剂， 生成 4-hydroxy-1-(2-[isopropyl(methyl)amino]quinolin-6-yl)pyridine-2(1H)-one
  参考文献：
  名称：

  Bicyclic aromatic substituted pyridone derivative

  摘要：

  本发明揭示了一种化合物，其化学式为（I）：其中R1和R2分别代表氢原子、低碳烷基或类似物；X1、X2和X3分别代表亚甲基基团或氮原子；Y1和Y3分别代表单键、—O—或类似物；Y2代表低碳烷基基团或类似物；W1至W4独立地代表单键、亚甲基基团或类似物；L代表单键、亚甲基基团或类似物；Z1和Z2独立地代表单键、C1-4烷基基团或类似物；Ar1代表芳香环烷基环或类似物；Ar2代表双环芳香环烷基环或类似物。该化合物可用作治疗中枢疾病、心血管疾病或代谢性疾病的药物。

  公开号：

  US20090264426A1

文献信息

• BICYCLIC AROMATIC SUBSTITUTED PYRIDONE DERIVATIVE
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1939194A1

  公开（公告）日：2008-07-02

  Disclosed is a compound represented by the formula (I): Wherein R1 and R2 independently represent a hydrogen atom, a lower alkyl group or the like; X1 , X2 and X3 independently represent a methine group or a nitrogen atom; Y1 and Y3 independently represent a single bond, -O- or the like; Y2 represents a lower alkylene group or the like; W1 to W4 independently represent a single bond, a methylene group or the like; L represents a single bond, a methylene group or the like; Z1 and Z2 independently represent a single bond, a C1-4 alkylene group or the like; Ar1 represents an aromatic carbocyclic ring or the like; and Ar2 represents a bicyclic aromatic carbocyclic ring or the like. The compound is useful as a pharmaceutical for a central disease, a cardiovascular disease or a metabolic disease.

  本发明公开了一种由式 (I) 表示的化合物： 其中 R1 和 R2 独立地代表氢原子、低级烷基或类似物；X1、X2 和 X3 独立地代表甲基或氮原子；Y1 和 Y3 独立地代表单键、-O- 或类似物；Y2 代表低级亚烷基或类似物；W1 至 W4 独立地代表单键、亚甲基或类似物；L 代表单键、亚甲基或类似物；Z1 和 Z2 独立地代表单键、C1-4 亚烷基或类似物；Ar1 代表芳香碳环或类似物；Ar2 代表双环芳香碳环或类似物。该化合物可用作治疗中枢疾病、心血管疾病或代谢疾病的药物。
• WO2007/29847
  申请人：——

  公开号：——

  公开（公告）日：——
• Bicyclic aromatic substituted pyridone derivative
  申请人：Sakuraba Shunji

  公开号：US20090264426A1

  公开（公告）日：2009-10-22

  Disclosed is a compound represented by the formula (I): Wherein R 1 and R 2 independently represent a hydrogen atom, a lower alkyl group or the like; X 1 , X 2 and X 3 independently represent a methine group or a nitrogen atom; Y 1 and Y 3 independently represent a single bond, —O— or the like; Y 2 represents a lower alkylene group or the like; W1 to W4 independently represent a single bond, a methylene group or the like; L represents a single bond, a methylene group or the like; Z 1 and Z 2 independently represent a single bond, a C 1-4 alkylene group or the like; Ar 1 represents an aromatic carbocyclic ring or the like; and Ar 2 represents a bicyclic aromatic carbocyclic ring or the like. The compound is useful as a pharmaceutical for a central disease, a cardiovascular disease or a metabolic disease.

  本发明揭示了一种化合物，其化学式为（I）：其中R1和R2分别代表氢原子、低碳烷基或类似物；X1、X2和X3分别代表亚甲基基团或氮原子；Y1和Y3分别代表单键、—O—或类似物；Y2代表低碳烷基基团或类似物；W1至W4独立地代表单键、亚甲基基团或类似物；L代表单键、亚甲基基团或类似物；Z1和Z2独立地代表单键、C1-4烷基基团或类似物；Ar1代表芳香环烷基环或类似物；Ar2代表双环芳香环烷基环或类似物。该化合物可用作治疗中枢疾病、心血管疾病或代谢性疾病的药物。