4-羟基吡喃-2-酮 | 50607-32-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 中文名称: 4-羟基吡喃-2-酮
• 中文别名: 9H-咔唑-d8(9CI)
• 英文名称: 4-hydroxy-2H-pyran-2-one
• 英文别名: 4-Hydroxy-2H-pyran-2-on；4-Hydroxypyran-2-one
• CAS: 50607-32-4
• 化学式: C₅H₄O₃
• 分子量: 112.085
• InChiKey: VNZOLPIHDIJPBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  4-羟基吡喃-2-酮 生成 5,6-dihydro-2H-pyran-2,4-dione
  参考文献：
  名称：

  KODZIMA, SIGEHRU;OKABEH, TAKASI;OISI, XARUXITO;TANINAKA, CATOPY

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl 5,5-diethoxy-3-oxopentanoate 在 盐酸 、 氢氧化钾 、 硫酸 、 三氧化硫 作用下， 以 乙醇 为溶剂， 反应 25.0h， 生成 4-羟基吡喃-2-酮
  参考文献：
  名称：

  Effenberger, Franz; Ziegler, Thomas; Schoenwaelder, Karl-Heinz, Chemische Berichte, 1985, vol. 118, # 2, p. 741 - 752

  摘要：

  DOI：

文献信息

• Vinyl esters as effective acetaldehyde surrogates in [4 + 1] cycloaddition based multicomponent cascade
  作者：Manoj Kumar、Sourav Bagchi、Anuj Sharma

  DOI：10.1039/c5ra10073a

  日期：——

  A new multicomponent cascade has been designed by utilizing vinyl esters as effective acetaldehyde surrogate. While most of the cyclic α-ketoenols underwent a facile three component conversion to annulated furans, phenols such as naphthol and sesamol got simply acylated under the same reaction conditions. This microwave assisted method provides clean access to a wide range of functionalised furans

  通过利用乙烯基酯作为有效的乙醛替代物，设计了一种新的多组分级联反应。尽管大多数环状α-酮烯醇都容易地由三组分转化为环状呋喃，但在相同的反应条件下，酚（如萘酚和芝麻酚）却被简单地酰化了。这种微波辅助方法可在短时间内清洁范围广泛的功能化呋喃。
• Bicyclic aromatic substituted pyridone derivative
  申请人：Sakuraba Shunji

  公开号：US20090264426A1

  公开（公告）日：2009-10-22

  Disclosed is a compound represented by the formula (I): Wherein R 1 and R 2 independently represent a hydrogen atom, a lower alkyl group or the like; X 1 , X 2 and X 3 independently represent a methine group or a nitrogen atom; Y 1 and Y 3 independently represent a single bond, —O— or the like; Y 2 represents a lower alkylene group or the like; W1 to W4 independently represent a single bond, a methylene group or the like; L represents a single bond, a methylene group or the like; Z 1 and Z 2 independently represent a single bond, a C 1-4 alkylene group or the like; Ar 1 represents an aromatic carbocyclic ring or the like; and Ar 2 represents a bicyclic aromatic carbocyclic ring or the like. The compound is useful as a pharmaceutical for a central disease, a cardiovascular disease or a metabolic disease.

  本发明揭示了一种化合物，其化学式为（I）：其中R1和R2分别代表氢原子、低碳烷基或类似物；X1、X2和X3分别代表亚甲基基团或氮原子；Y1和Y3分别代表单键、—O—或类似物；Y2代表低碳烷基基团或类似物；W1至W4独立地代表单键、亚甲基基团或类似物；L代表单键、亚甲基基团或类似物；Z1和Z2独立地代表单键、C1-4烷基基团或类似物；Ar1代表芳香环烷基环或类似物；Ar2代表双环芳香环烷基环或类似物。该化合物可用作治疗中枢疾病、心血管疾病或代谢性疾病的药物。
• [EN] MACROCYCLIC FACTOR XIA INHIBITORS CONDENSED WITH HETEROCYCLES<br/>[FR] INHIBITEURS MACROCYCLIQUES DU FACTEUR XIA CONDENSÉS À L'AIDE D'HÉTÉROCYCLES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2015116882A1

  公开（公告）日：2015-08-06

  The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

  本发明提供了化合物的公式(Ia):或其立体异构体、互变异构体或药学上可接受的盐，其中所有变量如本文所定义。这些化合物是选择性因子XIa抑制剂或FXIa和血浆激肽酶的双重抑制剂。本发明还涉及包含这些化合物的药物组合物以及使用它们治疗血栓栓塞和/或炎症性疾病的方法。
• Synthesis of 9H-furo [2,3-f]Chromene Derivatives by Promoting ZnO Nanoparticles
  作者：Faramarz Rostami-Charati、Zinatossadat Hossaini、Fatemeh Sheikholeslami-Farahani、Zahra Azizi、Seyyed Siadati

  DOI：10.2174/1386207318666150525094109

  日期：2015.10.21

  Three- component reactions of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, aldehydes and malononitrile or ethyl cyanoacetate in the presence of nanoparticles of ZnO as catalyst are explained as effective and green synthetic method for generating 9H- furo[2,3-f]chromenes in good yield.

  在纳米氧化锌颗粒作为催化剂的存在下，1-(6-羟基-2-异丙烯基-1-苯并呋喃基)-1-乙酮、醛类和丙二腈或氰基乙酸乙酯的三组分反应被解释为生成 9H- 呋喃并[2,3-f]色烯的有效绿色合成方法，且收率高。
• ZnO nanoparticles as a highly efficient heterogeneous catalyst for the synthesis of various chromene and pyrano[4,3-b]pyran derivatives under solvent-free conditions
  作者：Zinatossadat Hossaini、Fatemeh Sheikholeslami-Farahani、Samira Soltani、S. Zahra Sayyed-Alangi、Hadi Sajjadi-Ghotabadi

  DOI：10.1007/s10593-015-1654-0

  日期：2015.1

  or ethyl cyanoacetate in the presence of ZnO nanoparticles as the catalyst is described as an efficient and green synthetic method for obtaining of pyrano[4,3-b]pyran derivatives in excellent yield. These reactions were also tested with 2'-hydroxyacetophenone under similar conditions and produced chromene derivatives.

  4-羟基-2 H-吡喃-2-酮，醛与丙二腈或氰基乙酸乙酯的三组分反应在ZnO纳米粒子作为催化剂的存在下被描述为一种高效且绿色的合成吡喃酮的方法[4， 3- b ]吡喃衍生物具有优异的产率。这些反应也用2'-羟基苯乙酮在相似的条件下进行了测试，并生成了色烯衍生物。