毒理性
◉ 母乳喂养期间使用总结：目前没有关于艾卡特班特（icatibant）排入母乳的信息。由于艾卡特班特是一种分子量为1305 Da的蛋白质分子，母乳中的含量可能非常低。它还可能在婴儿的胃肠道中被部分破坏，婴儿的吸收可能很小。一名患者在哺乳期间安全地使用了该药物。在剂量后等待6小时再进行哺乳，应该可以最小化排入母乳中的药物量。
◉ 对哺乳婴儿的影响：一名患有遗传性血管性水肿的妇女在哺乳婴儿4个月大时开始根据需要使用艾卡特班特30毫克皮下注射治疗遗传性血管性水肿发作，并在服用艾卡特班特的同时继续哺乳了1年。剂量是在婴儿最长的睡眠期之前晚上注射的，并且在剂量后至少6小时才恢复哺乳。在面部和颈部肿胀以及腹痛的情况下，她立即自行给药，并给予配方奶代替母乳。两年后的第二次怀孕中，她在婴儿1个月大时使用了C1酯酶抑制剂，然后在婴儿1个月大时恢复使用艾卡特班特治疗。
◉ 对泌乳和母乳的影响：截至修订日期，没有找到相关的已发布信息。
◉ Summary of Use during Lactation:No information is available on the excretion of icatibant into breastmilk. Because icatibant is a protein molecule with a molecular weight of 1305 Da, the amount in milk is likely to be very low. It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal. One patient reportedly used the drug safely during breastfeeding. Waiting 6 hours after a dose before breastfeeding should minimize the amount of drug excreted into breastmilk.
◉ Effects in Breastfed Infants:A woman with hereditary angioedema began using icatibant 30 mg subcutaneously as needed for hereditary angioedema attacks when her breastfed infant was 4 months of age and continued breastfeeding for 1 year while taking icatibant. Doses were injected at night before the infant’s longest sleep period and breastfeeding was not resumed until at least 6 hours after a dose. In cases of swelling of the face and neck and abdominal pain, icatibant was immediately self-administered, and formula was given instead of breastmilk. In her second pregnancy 2 years later, she used C1 esterase inhibitor until the infant was 1 month of age, when she resumed icatibant therapy. .
◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.
来源:Drugs and Lactation Database (LactMed)
