9-Amino-3,4-dihydroacridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-Amino-3,4-dihydroacridine
• 英文别名: 3,4-dihydroacridin-9-amine
• 化学式: C₁₃H₁₂N₂
• 分子量: 196.252
• InChiKey: ISIFYDUQYVDLRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  维吖啶 生成 9-Amino-3,4-dihydroacridine
  参考文献：
  名称：

  SHUTSKE, GREGORY M.;PIERRAT, FRANK A.

  摘要：

  DOI：

文献信息

• 9-Amino-3,4-dihydroacridines and related compounds useful for enhancing
  申请人：Hoechst-Roussel Pharmaceuticals, Inc.

  公开号：US04839364A1

  公开（公告）日：1989-06-13

  There are disclosed compounds having the formula ##STR1## wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR.sub.2 where R.sub.2 is loweralkyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R.sub.1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C.dbd.O or CR.sub.5 OH where R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.Ch where CR.sub.5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.

  公开了具有以下式子的化合物：##STR1## 其中n为1，2或3；X为氢，低碳基，低碳氧基，卤素，羟基，硝基，三氟甲基，NHCOR.sub.2，其中R.sub.2为低碳基，或NR.sub.3 R.sub.4，其中R.sub.3和R.sub.4分别为氢或低碳基；R为氢或低碳基；R.sub.1为氢，低碳基，二低碳基氨基低碳基，芳基低碳基，二芳基低碳基，呋喃基低碳基，噻吩基低碳基，氧桥联芳基低碳基，氧桥联二芳基低碳基，氧桥联呋喃基低碳基或氧桥联噻吩基低碳基；Y为C.dbd.O或CR.sub.5 OH，其中R.sub.5为氢或低碳基；Z为CH.sub.2或C.dbd.CR.sub.6 R.sub.7，其中R.sub.6和R.sub.7独立地为氢或低碳基；或Y和Z一起为CR.sub.5.dbd.Ch，其中CR.sub.5和CH分别对应于Y和Z；其光学异构体，或其药学上可接受的酸加盐，其可用于增强记忆的方法，用于合成它们的方法，以及包含有效的增强记忆量的这种化合物的制药组合物。
• DERIVATIVES OF 9-AMINOACRIDINE HAVING PSYCHOTROPIC, ANTIAMNESTIC AND LIPID REGULATING PROPERTIES
  申请人：VSESOJUZNY NAUCHNY TSENTR PO BEZOPASNOTI BIOLOGICHESKI ACTIVNYKH VESHCHESTV

  公开号：EP0633251A1

  公开（公告）日：1995-01-11

  New chemical compounds, derivatives of 9-aminoacridine of general formula (I) where R = H, CH₃; R¹ = H, CH₃, Br; R² = H, CH₃; R³ = alkyl-C₁-C₅, arylmethyl, diethylaminoethyl; X = C = O, CHOH; Y = CH₂; X + Y = CH = CH; and their salts with organic and non-organic acids. The desired compounds are obtained by interaction of substituted nitriles of antranyl acid with dimedone with subsequent cyclization of intermediate enaminonitriles into corresponding ketones of 9-aminoacridine after the reduction of which and of their derivatives alkylated or aralkylated on the 9-amino group, the corresponding alcohols are obtained, after hydration of which 9-amino-3,4-dihydroacridines are obtained. When experimented on animals, the said derivatives of 9-aminoacridine have shown psychotropic, antiamnestic and lipid regulating properties, as well as a lower toxicity in comparison with known preparations.

  新的化合物，是9-氨基蒽醌的衍生物，其通式为(I)，其中R = H、CH₃；R¹ = H、CH₃、Br；R² = H、CH₃；R³ = 烷基-C₁-C₅、芳基甲基、二乙氨基乙基；X = C = O、CHOH；Y = CH₂；X + Y = CH = CH；以及它们与有机和非有机酸的盐。所需化合物是通过将替代的蒽酰胺基酸腈与二甲酮反应，随后将中间体烯胺腈环化成相应的9-氨基蒽醌酮，还原后得到它们及其衍生物烷基化或芳基烷基化的相应醇，水合后得到9-氨基-3,4-二氢蒽醌。在动物实验中，所述9-氨基蒽醌的衍生物表现出精神药理、抗遗忘和调脂作用，并且与已知制剂相比毒性更低。
• 9-Amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0179383B1

  公开（公告）日：1991-05-29
• SHUTSKE, GREGORY M.;PIERRAT, FRANK A.
  作者：SHUTSKE, GREGORY M.、PIERRAT, FRANK A.

  DOI：——

  日期：——
• SHUTSKA, GREGORY M.;PIERRAT, FRANK A.
  作者：SHUTSKA, GREGORY M.、PIERRAT, FRANK A.

  DOI：——

  日期：——