4-Phenylamino-3-quinolinecarbonitrile 8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-Phenylamino-3-quinolinecarbonitrile 8
• 英文别名: 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-(1-methylpiperidin-4-yl)oxyquinoline-3-carbonitrile
• 化学式: C₂₄H₂₄Cl₂N₄O₃
• 分子量: 487.386
• InChiKey: SRTONYAWGLMSSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  79.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,4-二氯-5-甲氧基苯胺 在 吡啶盐酸盐 、 sodium hydride 作用下， 以 乙二醇乙醚 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 4-Phenylamino-3-quinolinecarbonitrile 8
  参考文献：
  名称：

  7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as Dual Inhibitors of Src and Abl Kinases

  摘要：

  We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kinase.

  DOI：

  10.1021/jm0499458

文献信息

• 7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as Dual Inhibitors of Src and Abl Kinases
  作者：Diane H. Boschelli、Yanong D. Wang、Steve Johnson、Biqi Wu、Fei Ye、Ana Carolina Barrios Sosa、Jennifer M. Golas、Frank Boschelli

  DOI：10.1021/jm0499458

  日期：2004.3.1

  We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kinase.