2-methyl-1-[4-[4-(2-methylpropanoyl)phenyl]phenyl]propan-1-one | 60951-76-0

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 2-methyl-1-[4-[4-(2-methylpropanoyl)phenyl]phenyl]propan-1-one
• 英文别名: 4,4'-Diisobutyryl-biphenyl
• CAS: 60951-76-0
• 化学式: C₂₀H₂₂O₂
• 分子量: 294.393
• InChiKey: MRSISTCHAYIPPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methyl-1-[4-[4-(2-methylpropanoyl)phenyl]phenyl]propan-1-one 在 lithium aluminium tetrahydride 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 48.0h， 以56%的产率得到1-(4'-(1-chloro-2-methylpropyl)-[1,1'-biphenyl]-4-yl)-2-methylpropan-1-ol
  参考文献：
  名称：

  刚性多维烷氧基胺：多功能构建基块库

  摘要：

  从市售前体中以多步法合成了新颖的多维烷氧基胺库，具有很高的收率。简单的步骤可以生成线性，三角形平面，正方形平面和四面体形状的烷氧基胺。这些构建基块可用于经典的由氮氧化物介导的聚合反应，从而导致星形聚合物或氮氧化物交换反应，从而形成动态的可调框架。

  DOI：

  10.1002/ejoc.202001415
• 作为产物：
  描述：

  联苯 、 异丁酰氯 生成 2-methyl-1-[4-[4-(2-methylpropanoyl)phenyl]phenyl]propan-1-one
  参考文献：
  名称：

  Synthesis of Ketone Derivatives of Biphenyl by the Friedel-Crafts Reaction¹

  摘要：

  DOI：

  10.1021/ja01852a041

文献信息

• IAP BIR DOMAIN BINDING COMPOUNDS
  申请人：Laurent Alain

  公开号：US20100203012A1

  公开（公告）日：2010-08-12

  Disclosed herein is a compound of Formula 1: or a salt thereof, in which R 1 , R 1a , R 100 , R 100a , R 2 , R 200 , R 3 , R 300 , A, A 1 , Q, Q 1 and BG are as defined herein. Also disclosed is the use of the compounds of Formula 1 to treat disorders of dysregulated apoptosis, such as cancer and cellular proliferative disorders.
• BRIDGED SECONDARY AMINES AND USE THEREOF AS IAP BIR DOMAIN BINDING COMPOUNDS
  申请人：Laurent Alain

  公开号：US20110171171A1

  公开（公告）日：2011-07-14

  A compound of Formula 1.1A: 1.1A or salt thereof, as well as methods of making compounds of Formula 1.1A, methods of using compounds of Formula 1.1A to treat proliferative disorders such as cancer, and related compounds, composition, and methods.
• MEDICAL COMPOUND
  申请人：VERA SALUS RICERCA S.R.L.

  公开号：US20200323814A1

  公开（公告）日：2020-10-15

  Provided is a medical compound including a synthetic flavone derivative, according to the formula (I) with allotment in position C-3 of a group as shown below: wherein at least two of R 2 -R 6 are H, and the remaining are independently selected from: H, OH, R 1 , OR 1 , NO 2 , NH 2 , NHR 1 , F, Cl, Br, I, where R 1 is a radical.
• Rigid Multidimensional Alkoxyamines: A Versatile Building Block Library
  作者：Yannick Matt、Isabelle Wessely、Lisa Gramespacher、Manuel Tsotsalas、Stefan Bräse

  DOI：10.1002/ejoc.202001415

  日期：2021.1.15

  A library of novel, multidimensional alkoxyamines was synthesized in a multistep procedure from commercial precursors with very good yields. The easy procedures lead to linear, trigonal planar, square planar, and tetrahedral shaped alkoxyamines. These building blocks can be used for classical nitroxide mediated polymerization leading to star‐shaped polymers or nitroxide exchange reactions resulting

  从市售前体中以多步法合成了新颖的多维烷氧基胺库，具有很高的收率。简单的步骤可以生成线性，三角形平面，正方形平面和四面体形状的烷氧基胺。这些构建基块可用于经典的由氮氧化物介导的聚合反应，从而导致星形聚合物或氮氧化物交换反应，从而形成动态的可调框架。
• Synthesis of Ketone Derivatives of Biphenyl by the Friedel-Crafts Reaction¹
  作者：Loren M. Long、Henry R. Henze

  DOI：10.1021/ja01852a041

  日期：1941.7