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N4-Butyl-quinoline-3,4-diamine | 99010-20-5

中文名称
——
中文别名
——
英文名称
N4-Butyl-quinoline-3,4-diamine
英文别名
4-N-butylquinoline-3,4-diamine
N<sup>4</sup>-Butyl-quinoline-3,4-diamine化学式
CAS
99010-20-5
化学式
C13H17N3
mdl
——
分子量
215.298
InChiKey
HVLTUEHNJZLGIR-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.7
  • 重原子数:
    16
  • 可旋转键数:
    4
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.31
  • 拓扑面积:
    50.9
  • 氢给体数:
    2
  • 氢受体数:
    3

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    参考文献:
    名称:
    Synthesis and Structure−Activity-Relationships of 1H-Imidazo[4,5-c]quinolines That Induce Interferon Production
    摘要:
    1H-Imidazo-[4,5-c]quinolines were prepared while investigating novel nucleoside analogues as potential antiviral agents. While these compounds showed no direct antiviral activity when tested in a number of cell culture systems, some demonstrated potent inhibition of virus lesion development in an intravaginal guinea pig herpes simplex virus-2 assay. We have determined that the in vivo antiviral activity can be attributed to the ability of these molecules to induce the production of cytokines, especially interferon (IFN), in this model. Subsequently, we found that the compounds also induce in vitro production of IFN in human peripheral blood mononuclear cells (hPBMCs). The in vitro results reported herein and the in vivo results reported previously led to the discovery of imiquimod, 26, which was developed as a topical agent and has been approved for the treatment of genital warts, actinic keratosis, and superficial basal cell carcinoma.
    DOI:
    10.1021/jm049211v
  • 作为产物:
    描述:
    N-butyl-3-nitro-4-quinolinamine 在 platinum on activated charcoal 氢气 、 magnesium sulfate 作用下, 以 乙酸乙酯 为溶剂, 生成 N4-Butyl-quinoline-3,4-diamine
    参考文献:
    名称:
    Synthesis and Structure−Activity-Relationships of 1H-Imidazo[4,5-c]quinolines That Induce Interferon Production
    摘要:
    1H-Imidazo-[4,5-c]quinolines were prepared while investigating novel nucleoside analogues as potential antiviral agents. While these compounds showed no direct antiviral activity when tested in a number of cell culture systems, some demonstrated potent inhibition of virus lesion development in an intravaginal guinea pig herpes simplex virus-2 assay. We have determined that the in vivo antiviral activity can be attributed to the ability of these molecules to induce the production of cytokines, especially interferon (IFN), in this model. Subsequently, we found that the compounds also induce in vitro production of IFN in human peripheral blood mononuclear cells (hPBMCs). The in vitro results reported herein and the in vivo results reported previously led to the discovery of imiquimod, 26, which was developed as a topical agent and has been approved for the treatment of genital warts, actinic keratosis, and superficial basal cell carcinoma.
    DOI:
    10.1021/jm049211v
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文献信息

  • [EN] ARYLALKENYL AND ARYLALKYNYL SUBSTITUTED IMIDAZOQUINOLINES<br/>[FR] IMIDAZOQUINOLINES A SUBSTITUTION ARYLALCENYLE ET ARYLALKYNYLE
    申请人:3M INNOVATIVE PROPERTIES CO
    公开号:WO2005066170A1
    公开(公告)日:2005-07-21
    Arylalkenyl and aryalkynyl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
    本发明涉及芳基烯基和芳基炔基取代的咪唑喹啉化合物,含有这些化合物的药物组合物,中间体,以及将这些化合物用作免疫调节剂的方法,用于诱导动物体内的细胞因子合成,以及用于治疗包括病毒性和肿瘤性疾病在内的疾病。
  • Urea Substituted Imidazopyridines, Imidazoquinolines, and Imidazonaphthyridines
    申请人:Kshirsagar A. Tushar
    公开号:US20080015184A1
    公开(公告)日:2008-01-17
    Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having a urea substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    本发明涉及在2-位具有脲基的咪唑吡啶,咪唑喹啉和咪唑萘啶化合物,含有这些化合物的药物组合物,中间体以及这些化合物的制备方法和使用方法,作为免疫调节剂,在动物中调节细胞因子生物合成,并用于治疗包括病毒和肿瘤疾病在内的疾病。
  • ARYLALKENYL AND ARYLALKYNYL SUBSTITUTED IMIDAZOQUINOLINES
    申请人:3M Innovative Properties Company
    公开号:EP1701955A1
    公开(公告)日:2006-09-20
  • US4689338A
    申请人:——
    公开号:US4689338A
    公开(公告)日:1987-08-25
  • US4698348A
    申请人:——
    公开号:US4698348A
    公开(公告)日:1987-10-06
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