2-butyl-3-benzoylimidazo[1,2-a]pyridine | 1374639-81-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-butyl-3-benzoylimidazo[1,2-a]pyridine
• 英文别名: (2-Butylimidazo[1,2-a]pyridin-3-yl)-phenylmethanone；(2-butylimidazo[1,2-a]pyridin-3-yl)-phenylmethanone
• CAS: 1374639-81-2
• 化学式: C₁₈H₁₈N₂O
• 分子量: 278.354
• InChiKey: FCEXQJFPVBNHOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  34.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-哌啶-1-戊酮 在 四氯化钛 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 2-butyl-3-benzoylimidazo[1,2-a]pyridine
  参考文献：
  名称：

  Toward versatile methods leading to highly functionalized imidazo[1,2-a]pyridines

  摘要：

  A convenient and general method of preparation of polyfunctionalized imidazo[1,2-a]pyridines is reported. This methodology involves activation of secondary amides leading to the formation of the corresponding amidines 9. Different activating reagents have been evaluated and the efficiency of PCl5 was illustrated with alkyl functionalized groups. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.02.117

文献信息

• Toward versatile methods leading to highly functionalized imidazo[1,2-a]pyridines
  作者：Alexandra Basilio-Lopes、Thiago Mendonça de Aquino、Alexandre Mongeot、Jean-Jacques Bourguignon、Martine Schmitt

  DOI：10.1016/j.tetlet.2012.02.117

  日期：2012.5

  A convenient and general method of preparation of polyfunctionalized imidazo[1,2-a]pyridines is reported. This methodology involves activation of secondary amides leading to the formation of the corresponding amidines 9. Different activating reagents have been evaluated and the efficiency of PCl5 was illustrated with alkyl functionalized groups. (C) 2012 Elsevier Ltd. All rights reserved.