申请人:Watanabe Ken-ichi
公开号:US20060194857A1
公开(公告)日:2006-08-31
A heteroaryl derivative of the formula (1):
(wherein Ring Z is an optionally substituted heteroaryl, R
1
is a carboxyl group or an alkoxycarbonyl group, etc., W
1
and W
2
are an optionally substituted lower alkylene, Ar
1
is an optionally substituted arylene or an optionally substituted heteroarylene, W
3
is a single bond, a lower alkylene, a lower alkenylene, etc., W
4
is a single bond, —NR
10
—, etc., Ar
2
is an optionally substituted aryl or an optionally substituted heteroaryl), or a prodrug thereof, or a pharmaceutically acceptable salt thereof.
式(1)中,环Z是一种可选的取代杂环基,R1是羧基或烷氧羰基基团等,W1和W2是可选的取代的低碳基链,Ar1是可选的取代芳基或可选的取代杂芳基,W3是单键,低碳基链,低烯基链等,W4是单键,—NR10—等,Ar2是可选的取代芳基或可选的取代杂芳基的杂环基,或其前体药物,或其药物可接受的盐。