6-Morpholino-9-<2,3-O-isopropyliden-5-O-benzoyl-β-D-ribofuranosyl>-purin | 101502-44-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 6-Morpholino-9-<2,3-O-isopropyliden-5-O-benzoyl-β-D-ribofuranosyl>-purin
• 英文别名: O⁵-benzoyl-O²,O³-isopropylidene-1-(6-morpholin-4-yl-purin-9-yl)-β-D-1-deoxy-ribofuranose
• CAS: 101502-44-7
• 化学式: C₂₄H₂₇N₅O₆
• 分子量: 481.508
• InChiKey: VHARTFABMVEAAL-WGQQHEPDSA-N

反应信息

• 作为产物：
  描述：

  吗啉 、 2',3'-O-Isopropyliden-5'-O-benzoyl-inosin 生成 6-Morpholino-9-<2,3-O-isopropyliden-5-O-benzoyl-β-D-ribofuranosyl>-purin
  参考文献：
  名称：

  核苷和核苷酸的研究。23.一种替代嘌呤核苷的6-羟基基团的通用方法。

  摘要：

  2', 3'-O-Isopropylidene-5'-O-benzoylinosine and 2', 3', 5'-tri-O-benzoylinosine were reacted with N, N-dimethylformamide-thionyl chloride complex in chloroform solution. Resulting 6-chloro compound was further reacted with morpholine, dimethylamine and thiourea to afford 6-morpholino-, 6-dimethylamino-and 6-mercapto-derivative of 9-β-D-ribofuranosylpurine in a good overall yield.

  DOI：

  10.1248/cpb.12.267