methylated 3'-sialyl-lactose methyl ester | 115393-72-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methylated 3'-sialyl-lactose methyl ester
• CAS: 115393-72-1
• 化学式: C₃₆H₆₅NO₁₉
• 分子量: 815.907
• InChiKey: RDTXRMDJHUYMLB-MKJGVKEPSA-N

物化性质

• 沸点：
  780.4±60.0 °C(predicted)
• 密度：
  1.21±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  alpha-N-acetylneuraminyl-(2->3)-lactose 、 碘甲烷 生成 methylated 3'-sialyl-lactose methyl ester 、 methylated 3'-sialyl-lactose dimethylamide
  参考文献：
  名称：

  Analysis of sialic acid-containing mucin oligosaccharides from porcine small intestine by high-temperature gas chromatography-mass spectrometry of their dimethylamides

  摘要：

  Acetylation of sialic acid-containing oligosaccharides lactonises the sialic acid residue quantitatively for all oligosaccharides studied except for 6'-sialyl-lactose. The modified, unsulphated, sialylated and sulphated oligosaccharides can then be fractionated by anion-exchange chromatography. Ammonolysis of the lactones followed by methylation yielded the dimethylamides, which are amenable to g.l.c.-m.s. and give intense and informative mass spectra. This approach has been used to characterise the sialic acid-containing O-linked oligosaccharides obtained from the mucin glycopeptides of the small intestine of the pig. At least 28 structures were found, having NeuAc or NeuGc 6-linked to the HexNAc attached to the peptide core or to a Hex 3-linked to HexNAc. Four different disialylated oligosaccharides were found having NeuAc or NeuGc on the Hex residue 3-linked to HexNAc and 6-linked to HexNAc.

  DOI：

  10.1016/0008-6215(91)80055-r