(4S,5S)-8-Chloro-2,2,4-trimethyl-1,3-dioxa-spiro[4.4]non-8-en-7-one | 326858-32-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4S,5S)-8-Chloro-2,2,4-trimethyl-1,3-dioxa-spiro[4.4]non-8-en-7-one
• CAS: 326858-32-6
• 化学式: C₁₀H₁₃ClO₃
• 分子量: 216.664
• InChiKey: BASOQYVRCODZAJ-QUBYGPBYSA-N

反应信息

• 作为反应物：
  描述：

  (4S,5S)-8-Chloro-2,2,4-trimethyl-1,3-dioxa-spiro[4.4]non-8-en-7-one 在 盐酸 、 乙二醇 作用下， 以14.9 mg的产率得到(S)-2-Chloro-4-hydroxy-4-((S)-1-hydroxy-ethyl)-cyclopent-2-enone
  参考文献：
  名称：

  First total syntheses and configurational assignments of cytotoxic trichodenones A–C

  摘要：

  Total syntheses of cytotoxic trichodenones A-C, produced by a strain of Trichoderma harzianum from the sponge Halichondria okadai, have been achieved, and the natural trichodenones B and C have been established to have (4R,1'R)- and(1'R)-configurations, respectively. From this synthesis and chiral HPLC analysis, it was deduced that the major molecule with R-configuration coexists with its enantiomer in natural trichodenone A. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00329-3
• 作为产物：
  描述：

  (4S,5R)-8,9-Dichloro-2,2,4-trimethyl-1,3-dioxa-spiro[4.4]nonan-7-one 在 三乙胺 作用下， 以 乙醚 为溶剂， 反应 3.0h， 生成 (4S,5S)-8-Chloro-2,2,4-trimethyl-1,3-dioxa-spiro[4.4]non-8-en-7-one
  参考文献：
  名称：

  First total syntheses and configurational assignments of cytotoxic trichodenones A–C

  摘要：

  Total syntheses of cytotoxic trichodenones A-C, produced by a strain of Trichoderma harzianum from the sponge Halichondria okadai, have been achieved, and the natural trichodenones B and C have been established to have (4R,1'R)- and(1'R)-configurations, respectively. From this synthesis and chiral HPLC analysis, it was deduced that the major molecule with R-configuration coexists with its enantiomer in natural trichodenone A. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00329-3