| 275365-20-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 275365-20-3
• 化学式: C₅₂H₆₆N₄O₂₂S
• 分子量: 1131.18
• InChiKey: UTXJGTXFNFLIKF-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  以 溶剂黄146 为溶剂， 反应 0.02h， 以82%的产率得到2-methylsulfonylethyl 3-(2-methoxy-2-oxoethyl)-5-[[3-(2-methoxy-2-oxoethyl)-5-[[3-(2-methoxy-2-oxoethyl)-5-[[3-(2-methoxy-2-oxoethyl)-4-(3-methoxy-3-oxopropyl)-1H-pyrrol-2-yl]methyl]-4-(3-methoxy-3-oxopropyl)-1H-pyrrol-2-yl]methyl]-4-(3-methoxy-3-oxopropyl)-1H-pyrrol-2-yl]methyl]-4-(3-methoxy-3-oxopropyl)-1H-pyrrole-2-carboxylate
  参考文献：
  名称：

  Synthesis of a linear α-hydroxymethyl-pentapyrrole derivative and its cyclization to uroporphyrinogens

  摘要：

  A linear pentapyrrole bearing alpha-hydroxymeythyl group in the terminal was synthesized by the stepwise coupling of alpha-free pyrrole with azafulvenium ion 6. When it was treated with a catalytic amount of p-toluensulfonic acid under anaerobic condition, followed by aerial oxidation of the products, a statistical mixture of uroporphyrin I-IV octamethyl eaters was obtained. It is proposed that this transformation proceeds through a spiro-pyrrolenine as a key intermediate. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00293-8
• 作为产物：
  描述：

  4-(2-Methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid 2-methanesulfonyl-ethyl ester 在 disodium hydrogenphosphate 、 silver trifluoromethanesulfonate 、 溶剂黄146 、 锌 作用下， 以 四氢呋喃 、 溶剂黄146 、 乙腈 、 苯 为溶剂， 反应 11.37h， 生成
  参考文献：
  名称：

  Synthesis of a linear α-hydroxymethyl-pentapyrrole derivative and its cyclization to uroporphyrinogens

  摘要：

  A linear pentapyrrole bearing alpha-hydroxymeythyl group in the terminal was synthesized by the stepwise coupling of alpha-free pyrrole with azafulvenium ion 6. When it was treated with a catalytic amount of p-toluensulfonic acid under anaerobic condition, followed by aerial oxidation of the products, a statistical mixture of uroporphyrin I-IV octamethyl eaters was obtained. It is proposed that this transformation proceeds through a spiro-pyrrolenine as a key intermediate. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00293-8