| 304429-15-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• CAS: 304429-15-0
• 化学式: C₄₅H₅₈O₁₃
• 分子量: 806.948
• InChiKey: VTWNJPPNBSBTRM-HOWXKDLXSA-N

物化性质

• 沸点：
  895.2±65.0 °C(predicted)
• 密度：
  1.27±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  在 palladium dihydroxide 氢气 作用下， 以 乙酸乙酯 为溶剂， 以63%的产率得到[(1R,3S,7S,8E,11S,12S,13E,15S,17R,21R,23S)-11,21-dihydroxy-17-[(1R)-1-hydroxyethyl]-13-(2-methoxy-2-oxoethylidene)-10,10-dimethyl-19-oxo-6,18,27,28,29-pentaoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] benzoate
  参考文献：
  名称：

  Synthesis and biological evaluation of a new class of bryostatin analogues: the role of the C20 substituent in protein kinase C binding

  摘要：

  The synthesis and biological assay of a new series of designed bryostatin analogues modified at the C20 position are described. These compounds are found to bind to protein kinase C with affinities of up to 1.5 nM, demonstrating that variations at C20 can indeed be used to tune affinity and potentially function. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01100-x
• 作为产物：
  描述：

  在 氟化氢吡啶 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and biological evaluation of a new class of bryostatin analogues: the role of the C20 substituent in protein kinase C binding

  摘要：

  The synthesis and biological assay of a new series of designed bryostatin analogues modified at the C20 position are described. These compounds are found to bind to protein kinase C with affinities of up to 1.5 nM, demonstrating that variations at C20 can indeed be used to tune affinity and potentially function. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01100-x