| 604809-72-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 604809-72-5
• 化学式: C₅₈H₈₁N₇O₁₂S₂
• 分子量: 1132.45
• InChiKey: SLXQFKLGTAYPKU-ISJQMEFQSA-N

反应信息

• 作为反应物：
  描述：

  在 三乙基硅烷 、 甲基乙基硫醚 、 三氟乙酸 作用下， 生成 (2S,3R)-N-[(3S,6S,9S,12S,15R)-9-benzyl-6-[(2S)-butan-2-yl]-12-methyl-3-(2-methylsulfanylethyl)-2,5,8,11,14-pentaoxo-1-thia-4,7,10,13-tetrazacyclohexadec-15-yl]-2-[[(2S)-2-[4-(4-benzylphenoxy)butanoylamino]-3-hydroxypropanoyl]amino]-3-hydroxybutanamide
  参考文献：
  名称：

  Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system

  摘要：

  The expression of many staphylococcal virulence factors are regulated by the agr locus via a two-component signal transduction system (TCSTS), which is activated in response to a secreted autoinducer peptide (AIP). By exploiting the unique chemical architecture of the naturally occurring AIP-1, several potent inhibitors of staphylococcal TCSTS were designed and synthesized using either a linear or branched solid-phase approach. These inhibitors are competitive binders and contain the crucial 16-membered side-chain-to-tail thiolactone peptide pharmacophore. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00497-9
• 作为产物：
  描述：

  在 N-羟基-7-氮杂苯并三氮唑 、 N-polystyrene methyl-N'-cyclohexylcarbodiimide 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system

  摘要：

  The expression of many staphylococcal virulence factors are regulated by the agr locus via a two-component signal transduction system (TCSTS), which is activated in response to a secreted autoinducer peptide (AIP). By exploiting the unique chemical architecture of the naturally occurring AIP-1, several potent inhibitors of staphylococcal TCSTS were designed and synthesized using either a linear or branched solid-phase approach. These inhibitors are competitive binders and contain the crucial 16-membered side-chain-to-tail thiolactone peptide pharmacophore. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00497-9