| 1202635-26-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1202635-26-4
• 化学式: C₂₀H₁₈F₃N₅O₃
• 分子量: 433.39
• InChiKey: IFRFTTSBQDGAET-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  N-叔丁氧羰基-L-丙氨酸 、 在 1-羟基苯并三唑 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以55%的产率得到
  参考文献：
  名称：

  1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)

  摘要：

  We have identified the N-1-benzyl-N-2-methylethane-1,2-diamine unit as a substitute for the (S)-alanine benzylamide moiety for the design of co-activator associated arginine methyltransferase 1 (CARM1) inhibitors. The potency of these inhibitors is in the same order of magnitude as their predecessors and their clearance, volume of distribution, and half lives were greatly improved. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.110
• 作为产物：
  描述：

  在 盐酸羟胺 、 碳酸氢钠 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以60%的产率得到
  参考文献：
  名称：

  1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)

  摘要：

  We have identified the N-1-benzyl-N-2-methylethane-1,2-diamine unit as a substitute for the (S)-alanine benzylamide moiety for the design of co-activator associated arginine methyltransferase 1 (CARM1) inhibitors. The potency of these inhibitors is in the same order of magnitude as their predecessors and their clearance, volume of distribution, and half lives were greatly improved. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.110