| 1202635-25-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1202635-25-3
• 化学式: C₂₈H₃₀F₃N₇O₄
• 分子量: 585.586
• InChiKey: IIRNYHYOTRRSQE-INIZCTEOSA-N

反应信息

• 作为反应物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以54%的产率得到(S)-1-(3-(5-(1-aminoethyl)-1H-1,2,4-triazol-3-yl)phenyl)-N-(2-methoxybenzyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
  参考文献：
  名称：

  1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)

  摘要：

  We have identified the N-1-benzyl-N-2-methylethane-1,2-diamine unit as a substitute for the (S)-alanine benzylamide moiety for the design of co-activator associated arginine methyltransferase 1 (CARM1) inhibitors. The potency of these inhibitors is in the same order of magnitude as their predecessors and their clearance, volume of distribution, and half lives were greatly improved. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.110
• 作为产物：
  描述：

  、 N-tert-butoxycarbonyl-L-alanine hydrazide 在 盐酸 、 甲醇 、 三乙胺 作用下， 以 乙醚 、 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 8.83h， 生成
  参考文献：
  名称：

  1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)

  摘要：

  We have identified the N-1-benzyl-N-2-methylethane-1,2-diamine unit as a substitute for the (S)-alanine benzylamide moiety for the design of co-activator associated arginine methyltransferase 1 (CARM1) inhibitors. The potency of these inhibitors is in the same order of magnitude as their predecessors and their clearance, volume of distribution, and half lives were greatly improved. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.110