| 1132670-51-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1132670-51-9
• 化学式: C₂₀H₂₈ClN₃O
• 分子量: 361.915
• InChiKey: IGYMGTRRFBSCKI-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 manganese(IV) oxide 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以29%的产率得到(4-chlorophenyl)(1-methyl-2-(4-(piperidin-1-yl)butyl)-1H-imidazol-5-yl)methanone
  参考文献：
  名称：

  Novel imidazole-based histamine H3 antagonists

  摘要：

  A novel series of imidazole containing histamine H-3 receptor ligands were investigated and found to be potent functional antagonists. After improving the stability of these molecules towards liver microsomes, these compounds were found to have no appreciable affinity for CYP P450s. Subsequent in vivo experiments showed significant brain uptake of (4-chloro-phenyl)-[2-(1-isopropyl-piperidin-4-ylmethoxy)-3-methyl-3H-imidazol-4-yl]-methanone 22. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.114
• 作为产物：
  描述：

  、 4-氯苯甲醛 在 2,2,6,6-四甲基哌啶 、 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 11.0h， 以56%的产率得到
  参考文献：
  名称：

  Novel imidazole-based histamine H3 antagonists

  摘要：

  A novel series of imidazole containing histamine H-3 receptor ligands were investigated and found to be potent functional antagonists. After improving the stability of these molecules towards liver microsomes, these compounds were found to have no appreciable affinity for CYP P450s. Subsequent in vivo experiments showed significant brain uptake of (4-chloro-phenyl)-[2-(1-isopropyl-piperidin-4-ylmethoxy)-3-methyl-3H-imidazol-4-yl]-methanone 22. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.114