(3aS,7aR)-1-(4-methoxybenzyl)-3a-[(methylsulfanyl)-methoxy]-7a-(1H-indol-1-ylcarbonyl)octahydro-2H-indol-2-one | 1185252-53-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (3aS,7aR)-1-(4-methoxybenzyl)-3a-[(methylsulfanyl)-methoxy]-7a-(1H-indol-1-ylcarbonyl)octahydro-2H-indol-2-one
• CAS: 1185252-53-2
• 化学式: C₂₇H₃₀N₂O₄S
• 分子量: 478.612
• InChiKey: PMWFALSEIRWHDQ-SVBPBHIXSA-N

反应信息

• 作为反应物：
  描述：

  (3aS,7aR)-1-(4-methoxybenzyl)-3a-[(methylsulfanyl)-methoxy]-7a-(1H-indol-1-ylcarbonyl)octahydro-2H-indol-2-one 在 水 、 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以77%的产率得到(3aS,7aR)-1-(4-methoxybenzyl)-3a-[(methylsulfanyl)-methoxy]-2-oxooctahydro-7aH-indole-7a-carboxylic acid
  参考文献：
  名称：

  Propellane as a conformational device for the stabilization of the β-lactone of salinosporamide A

  摘要：

  The synthesis of a propellane derivative of salinosporamide A having increased stability under physiological-like conditions is reported. The synthesis took advantage of a substrate-controlled stereoselective Ugi 4-center 3-component reaction to construct the required syn-bicyclic pyroglutamic acid framework. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.05.085
• 作为产物：
  描述：

  (3aS)-N-[2-(2,2-dimethoxyethyl)phenyl]-1-(4-methoxybenzyl)-3a-[(methylsulfanyl)methoxy]-2-oxooctahydro-7aH-indole-7a-carboxamide 在 溶剂黄146 、 三氟乙酸 作用下， 以 苯 为溶剂， 反应 4.0h， 以73%的产率得到(3aS,7aR)-1-(4-methoxybenzyl)-3a-[(methylsulfanyl)-methoxy]-7a-(1H-indol-1-ylcarbonyl)octahydro-2H-indol-2-one
  参考文献：
  名称：

  Propellane as a conformational device for the stabilization of the β-lactone of salinosporamide A

  摘要：

  The synthesis of a propellane derivative of salinosporamide A having increased stability under physiological-like conditions is reported. The synthesis took advantage of a substrate-controlled stereoselective Ugi 4-center 3-component reaction to construct the required syn-bicyclic pyroglutamic acid framework. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.05.085