p-acetylphenylacetic anhydride | 1287189-32-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: p-acetylphenylacetic anhydride
• CAS: 1287189-32-5
• 化学式: C₂₀H₁₈O₅
• 分子量: 338.36
• InChiKey: HRFQPXYCSQJGEE-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  p-acetylphenylacetic anhydride 、 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Synthetic and Immunological Studies of sTn Derivatives Carrying Substituted Phenylacetylsialic Acids as Cancer Vaccine Candidate

  摘要：

  To search for effective cancer vaccines based on sTn, a sialylated tumor-associated carbohydrate antigen (sialo-TACA) expressed by a number of tumors, four unnatural N-acyl sTn derivatives, including 5'-N-p-methylphenylacetyl sTn (sTnNMePhAc), S'-N-p-methoxylphenylacetyl sTn (sTnNMeOPhAc), 5'-N-p-acetylphenylacetyl sTn (sTnNAcPhAc), and 5'-N-p-chlorophenylacetyl sTn (sTnNClPhAc), as well as their protein conjugates, were synthesized by a highly convergent procedure. The immunological properties of these sTn derivatives in the form of keyhole limpet hemocyanin conjugate were evaluated in mice and compared to that of sTnNPhAc, a sTn derivative previously investigated as a vaccine candidate. It was shown that sTnNMePhAc, sTnNMeOPhAc, sTnNAcPhAc, and sTnNClPhAc are all much more immunogenic than sTnNPhAc and t(h)at they provoked strong T cell-dependent IgG1 immune responses useful for cancer immunotherapy. It was concluded that sTnNClPhAc is a promising candidate for cancer vaccine development and is worthy of further investigation.

  DOI：

  10.1021/ml100313d