2-hydroxy-5-(phenylamino)benzaldehyde | 1456898-76-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-hydroxy-5-(phenylamino)benzaldehyde
• CAS: 1456898-76-2
• 化学式: C₁₃H₁₁NO₂
• 分子量: 213.236
• InChiKey: KACHXNVEMVIMFE-UHFFFAOYSA-N

物化性质

• 沸点：
  338.4±27.0 °C(predicted)
• 密度：
  1.287±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  2-hydroxy-5-(phenylamino)benzaldehyde 、 乙酰乙酸乙酯 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以42%的产率得到3-acetyl-6-(phenylamino)-2H-chromen-2-one
  参考文献：
  名称：

  Synthesis of Novel Coumarin Derivatives and in vitro Biological Evaluation as Potential PTP 1B Inhibitors

  摘要：

  The aim of protein tyrosine phosphatase 1B (PTP 1B) inhibitors is to develop effective drug for diabetes and obesity. Coumarin becomes as a good skeleton, and is often applied in drug design and synthesis. In this paper, we have synthesized a series of novel coumarin derivatives to be as potential PTP 1B inhibitors. The inhibition rate of compound 9 was more than 80%, and the IC50 value was 49.2 mu M, which would be considered for further study.

  DOI：

  10.3987/com-13-12730