O-(3,6-di-O-acetyl-4-O-benzyl-2-deoxy-2-fluoro-α-D-glucopyranosyl)-trichloroacetimidate | 1427042-92-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O-(3,6-di-O-acetyl-4-O-benzyl-2-deoxy-2-fluoro-α-D-glucopyranosyl)-trichloroacetimidate
• CAS: 1427042-92-9
• 化学式: C₁₉H₂₁Cl₃FNO₇
• 分子量: 500.736
• InChiKey: MVMGMXSMDAUUGI-WRQOLXDDSA-N

反应信息

• 作为产物：
  描述：

  [(2R,3R,4S,5R)-4-acetyloxy-5-fluoro-6-hydroxy-3-phenylmethoxyoxan-2-yl]methyl acetate 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三氯乙腈 作用下， 以 二氯甲烷 为溶剂， 生成 O-(3,6-di-O-acetyl-4-O-benzyl-2-deoxy-2-fluoro-α-D-glucopyranosyl)-trichloroacetimidate 、 O-(3,6-di-O-acetyl-4-O-benzyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)-trichloroacetimidate
  参考文献：
  名称：

  Synthesis of a Dual-Purpose 2-Deoxy-2-fluoro-glucopyranosyl Building Block

  摘要：

  We demonstrate a straightforward route to 1,3,6-tri-O-acetyl-4-O-benzyl-2-deoxy-2-fluoro-D-glucopyranose through potassium hydrogen fluoride opening of a erny epoxide under microwave irradiation followed by acetolysis. The fluoroglucose building block was used as a key intermediate in the synthesis of 2,2-dideoxy-2,2-difluoromaltose. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.

  DOI：

  10.1080/00397911.2011.648001