| 1448018-52-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1448018-52-7
• 化学式: C₁₂H₁₇IO₄
• 分子量: 352.169
• InChiKey: GLZOUGMQTNESDE-BRJGQOAXSA-N

反应信息

• 作为反应物：
  描述：

  重氮乙酸乙酯 、 在 tin(ll) chloride 作用下， 反应 2.0h， 以72%的产率得到ethyl 4-[(3aR,5S,6R,6aR)-5-[(Z)-2-iodoprop-1-enyl]-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-yl]-3-oxobutanoate
  参考文献：
  名称：

  A macrolactonisation approach to the cembrane carbocycle of bielschowskysin

  摘要：

  By judicious choice of a conformationally constraining unit to predispose cyclisation to a 15-membered ring, we present a straightforward strategy to a cembranolide precursor of bielschowskysin by the Sonogashira coupling of two readily prepared fragments (from D-glucose and L-malic acid) followed by a facile beta-acylketene macrolactonisation reaction. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.012
• 作为产物：
  描述：

  在 2-碘酰基苯甲酸 作用下， 以 乙酸乙酯 为溶剂， 反应 3.0h， 以100%的产率得到
  参考文献：
  名称：

  A macrolactonisation approach to the cembrane carbocycle of bielschowskysin

  摘要：

  By judicious choice of a conformationally constraining unit to predispose cyclisation to a 15-membered ring, we present a straightforward strategy to a cembranolide precursor of bielschowskysin by the Sonogashira coupling of two readily prepared fragments (from D-glucose and L-malic acid) followed by a facile beta-acylketene macrolactonisation reaction. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.012