| 1015477-08-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1015477-08-3
• 化学式: C₁₈H₁₈N₂O₃S
• 分子量: 342.419
• InChiKey: RSVGXMOWRZQLLJ-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  硫氰酸铵 、 2-(3,4-dimethoxyanilino)-1-(4-methoxyphenyl)ethanone 在 盐酸 作用下， 反应 1.5h， 生成
  参考文献：
  名称：

  Design, synthesis, and in vitro antitumor activity of new 1,4-diarylimidazole-2-ones and their 2-thione analogues

  摘要：

  A series of new 1,4-diarylimidazol-2(3H)-one derivatives and their 2-thione analogues has been prepared and evaluated in vitro for antitumor activity against the NCI human cancer cell panel. Compounds bearing a 3,4,5-trimethoxyphenyl ring linked to either N-1 or C-4 position of the imidazole core demonstrated an interesting profile of cytotoxicity with preferential activity against leukemic cell lines. Compound 13 exhibited a potent antitumor activity against MOLT-4 (GI(50) = 20 nM) and SR (GI(50) = 32 nM) cell lines. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.023