methyl 2-[1-(3-bromo-2,2-dimethoxy-propionylamino)-2-hydroxy-propyl]-5-phenyl-oxazole-4-carboxylate | 1064764-42-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl 2-[1-(3-bromo-2,2-dimethoxy-propionylamino)-2-hydroxy-propyl]-5-phenyl-oxazole-4-carboxylate
• CAS: 1064764-42-6
• 化学式: C₁₉H₂₃BrN₂O₇
• 分子量: 471.305
• InChiKey: GYOIPJPQWXDFEF-YPMHNXCESA-N

反应信息

• 作为反应物：
  描述：

  methyl 2-[1-(3-bromo-2,2-dimethoxy-propionylamino)-2-hydroxy-propyl]-5-phenyl-oxazole-4-carboxylate 在 二乙胺基三氟化硫 、 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and Antitumor Activity of Mechercharmycin A Analogues

  摘要：

  Several analogues of the cytotoxic thiopeptide IB-01211 or mechercharmycin A (1) have been synthesized. The cytotoxicity of 1 and the synthesized analogues were evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives 2 and 3c were chosen for further studies on effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis were detected.

  DOI：

  10.1021/jm800513w
• 作为产物：
  描述：

  bromopiruvic acid dimethyl acetal 、 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 生成 methyl 2-[1-(3-bromo-2,2-dimethoxy-propionylamino)-2-hydroxy-propyl]-5-phenyl-oxazole-4-carboxylate
  参考文献：
  名称：

  Synthesis and Antitumor Activity of Mechercharmycin A Analogues

  摘要：

  Several analogues of the cytotoxic thiopeptide IB-01211 or mechercharmycin A (1) have been synthesized. The cytotoxicity of 1 and the synthesized analogues were evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives 2 and 3c were chosen for further studies on effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis were detected.

  DOI：

  10.1021/jm800513w