2-(2',3',4'-tri-O-benzoyl-β-D-galactopyranosyl)-1,4-dimethoxybenzene | 1093850-36-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2',3',4'-tri-O-benzoyl-β-D-galactopyranosyl)-1,4-dimethoxybenzene
• CAS: 1093850-36-2
• 化学式: C₃₅H₃₂O₁₀
• 分子量: 612.633
• InChiKey: GJALMVYOJCKLAV-LIRVCHIBSA-N

反应信息

• 作为反应物：
  描述：

  2-(2',3',4'-tri-O-benzoyl-β-D-galactopyranosyl)-1,4-dimethoxybenzene 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of triazole-linked β-C-glycosyl dimers as inhibitors of PTP1B

  摘要：

  Protein tyrosine phosphatase 1B (PTP1B) has emerged as a promising target for type 2 diabetes. We have successfully synthesized dimeric acetylated and benzoylated beta-C-D-glucosyl and beta-C-D-galactosyl 1,4-dimethoxy benzenes or naphthalenes by click chemistry. These compounds were further transformed into the corresponding beta-C-D-glycosyl-1,4-quinone derivatives by CAN oxidation. The in vitro inhibition test showed that dimeric benzoylated beta-C-D-glycosyl 1,4-dimethoxybenzenes or 1,4-benzoquinones were good inhibitors of PTP1B (IC50: 0.62-0.88 mu M), with no significant difference between gluco and galacto derivatives. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.09.066
• 作为产物：
  描述：

  2-(2',3',4'-tri-O-benzoyl-6'-O-triphenylmethyl-β-D-galactopyranosyl)-1,4-dimethoxybenzene 在 水 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以56%的产率得到2-(2',3',4'-tri-O-benzoyl-β-D-galactopyranosyl)-1,4-dimethoxybenzene
  参考文献：
  名称：

  Synthesis of triazole-linked β-C-glycosyl dimers as inhibitors of PTP1B

  摘要：

  Protein tyrosine phosphatase 1B (PTP1B) has emerged as a promising target for type 2 diabetes. We have successfully synthesized dimeric acetylated and benzoylated beta-C-D-glucosyl and beta-C-D-galactosyl 1,4-dimethoxy benzenes or naphthalenes by click chemistry. These compounds were further transformed into the corresponding beta-C-D-glycosyl-1,4-quinone derivatives by CAN oxidation. The in vitro inhibition test showed that dimeric benzoylated beta-C-D-glycosyl 1,4-dimethoxybenzenes or 1,4-benzoquinones were good inhibitors of PTP1B (IC50: 0.62-0.88 mu M), with no significant difference between gluco and galacto derivatives. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.09.066