sagittacin B | 1613367-20-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: sagittacin B
• CAS: 1613367-20-6
• 化学式: C₂₃H₃₀O₈
• 分子量: 434.486
• InChiKey: NVWMBQADEBVEQI-REVSWVOISA-N

反应信息

• 作为反应物：
  描述：

  sagittacin B 在 甲醇 、 potassium carbonate 作用下， 反应 10.0h， 以0.6 mg的产率得到sagittacin A
  参考文献：
  名称：

  Eremophilane-Type Sesquiterpenoids with Diverse Skeletons from Ligularia sagitta

  摘要：

  Five new highly oxygenated eremophilane-type sesquiterpenoids, possessing C-19 (1 and 2), C-15 (3 and 4), and C-14 (8) skeletons, along with eight known eremophilenolides were obtained from the aerial parts of Ligularia sagitta. The absolute configuration of 1 was assigned by X-ray diffraction analysis and that of 3 by ECD spectroscopy. Compounds 1-10 were evaluated for their antibacterial activities against Staphyloccocus aureus, Bacillus subtilis, Escherichia colt, Bacillus cereus, and Erwinia carotovora. Compounds 4 and 5 displayed broad-spectrum inhibitory activity against these bacteria with MIC values of approximately 7.25 mu g/mL, followed by 3 and 6 with MIC values in the range of 23.0-125.0 mu g/mL. Compounds 3 and 8 showed mild activity against three human tumor cell lines (IC50 approximate to 13 mu M). Preliminary structure activity relationships for these eremophilenolides are reported.

  DOI：

  10.1021/np5003302