| 1095601-75-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1095601-75-4
• 化学式: C₂₁H₃₄O₇Si
• 分子量: 426.582
• InChiKey: JARQGRMWSMOCOW-HOBVGZPTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.75
• 重原子数：
  29.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  80.29
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  1,3-丙二硫醇 、 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 以38.6 mg的产率得到C₂₁H₃₂O₆S₂
  参考文献：
  名称：

  Stereoselective Synthesis of trans-Fused 7,6,6,7-Membered Tetracyclic Ether, Corresponding to the EFGH-Ring of Gambierol and the BCDE-Ring of Gambieric Acids

  摘要：

  Stereoselective synthesis of a trans-fused 7,6,6,7-membered tetracyclic ether, corresponding to the EFGH-ring of gambierol and the BCDE-ring of gambieric acids, was efficiently accomplished via a two-directional approach. The key reactions were SMI2-induced double cyclization for construction of the F- and H-rings and SMI2-induced cyclization followed by ring expansion for construction of the E-ring.

  DOI：

  10.1021/ol8024555
• 作为产物：
  描述：

  C₂₁H₃₆O₇Si 在 N-甲基吗啉氧化物 、 四丙基高钌酸铵 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Stereoselective Synthesis of trans-Fused 7,6,6,7-Membered Tetracyclic Ether, Corresponding to the EFGH-Ring of Gambierol and the BCDE-Ring of Gambieric Acids

  摘要：

  Stereoselective synthesis of a trans-fused 7,6,6,7-membered tetracyclic ether, corresponding to the EFGH-ring of gambierol and the BCDE-ring of gambieric acids, was efficiently accomplished via a two-directional approach. The key reactions were SMI2-induced double cyclization for construction of the F- and H-rings and SMI2-induced cyclization followed by ring expansion for construction of the E-ring.

  DOI：

  10.1021/ol8024555