| 1092497-66-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1092497-66-9
• 化学式: C₆₈H₉₉N₇O₁₅
• 分子量: 1254.57
• InChiKey: YHRMOKHGBRUYLX-MUZNEHLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  90.0
• 可旋转键数：
  22.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  231.8
• 氢给体数：
  1.0
• 氢受体数：
  20.0

反应信息

• 作为反应物：
  描述：

  在 甲醇 作用下， 反应 3.0h， 以70%的产率得到
  参考文献：
  名称：

  Synthesis and antibacterial activity of 4″-O-heteroarylcarbamoyl derivatives of macrolide

  摘要：

  A series of novel 4 ''-position modified macrolide derivatives has been synthesized via a facile procedure. Their in vitro antibacterial activities against constitutively erythromycin-resistant strains were evaluated. Among the derivatives tested, compound 8a which has 11,12-carbamate and 4 ''-O-heteroarylcarbamoyl groups was found to have potent activity against most resistant bacteria. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.09.022
• 作为产物：
  描述：

  、 4-(4-phenyl-1H-imidazol-1-yl)butan-1-amine 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 反应 10.0h， 生成
  参考文献：
  名称：

  Synthesis and antibacterial activity of 4″-O-heteroarylcarbamoyl derivatives of macrolide

  摘要：

  A series of novel 4 ''-position modified macrolide derivatives has been synthesized via a facile procedure. Their in vitro antibacterial activities against constitutively erythromycin-resistant strains were evaluated. Among the derivatives tested, compound 8a which has 11,12-carbamate and 4 ''-O-heteroarylcarbamoyl groups was found to have potent activity against most resistant bacteria. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.09.022