| 1190370-98-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1190370-98-9
• 化学式: C₃₈H₅₀Cl₃NO₂₄
• 分子量: 1011.17
• InChiKey: ZVGBRKIALBJBDK-CHMIAVGGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.96
• 重原子数：
  66.0
• 可旋转键数：
  16.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  315.93
• 氢给体数：
  1.0
• 氢受体数：
  25.0

反应信息

• 作为反应物：
  描述：

  、 在 三氟甲磺酸三甲基硅酯 作用下， 以 乙腈 为溶剂， 以53%的产率得到
  参考文献：
  名称：

  Block synthesis of blood group tetrasaccharides B (types 1, 3 and 4)

  摘要：

  3-Aminopropyl glycosides of the tetrasaccharides Gal alpha 1-3(Fuc alpha 1-2)Gal beta 1-3GlcNAc beta (B type 1), Gal alpha 1-3(Fuc alpha 1-2)Gal beta 1-3GalNAc alpha (B type 3), and Gal alpha 1-3(Fuc alpha 1-2)Gal beta 1-3GalNAc beta (B type 4) were synthesised using acetylated Gal alpha 1-3(Fuc alpha 1-2)Gal trichloroacetimidate 4 as a glycosyl donor at the key stage.

  DOI：

  10.1016/j.mencom.2009.05.013

文献信息

• Block synthesis of A (type 2) and B (type 2) tetrasaccharides related to the human ABO blood group system
  作者：Ivan M. Ryzhov、Elena Yu. Korchagina、Inna S. Popova、Tatiana V. Tyrtysh、Alexander S. Paramonov、Nicolai V. Bovin

  DOI：10.1016/j.carres.2016.04.029

  日期：2016.7

  Herein we report the synthesis of 3-aminopropyl glycosides of A (type 2) and B (type 2) tetrasaccharides via [3 + 1] block scheme. Peracetylated trichloroacetimidates of A and B trisaccharides were used as glycosyl donors. The well-known low reactivity of 4-OH group of N-acetyl-d-glucosamine forced us to test four glucosamine derivatives (3-Bz-1,6-anhydro-GlcNAc and 3-trifluoroacetamidopropyl β-glycosides

  在本文中，我们通过[3 +1]嵌段方案报告了A（2型）和B（2型）四糖的3-氨基丙基糖苷的合成。A和B三糖的全乙酰化三氯乙酰亚氨酸酯用作糖基供体。N-乙酰基-d-葡糖胺的4-OH基团众所周知的低反应性迫使我们测试四种葡糖胺衍生物（3-Ac-的3-Bz-1,6-anhydro-GlcNAc和3-三氟乙酰氨基丙基β-糖苷6-Bn-GlcNAc，3-Ac-6-Bn-GlcNc3和3-Ac-6-Bn-GlcNAc2）来选择用于合成2型四糖的最佳糖基受体。当3-Ac-6-Bn-GlcNAcβ的3-三氟乙酰氨基丙基糖苷被糖基化时，没有分离出所需的四肽。3-Bz-1，6-脱水-GlcNAc衍生物的糖基化产生α-糖苷作为主要产物。只有将3-三氟乙酰氨基丙基3-Ac-6-Bn-GlcNAc2β用作糖基受体（β/α5：1），而与A的三氯乙酰亚氨酸酯进行糖基化反应时，只有在B（2型）四糖的合成中才能实现高立体特异性。三糖不是立体定向的（β/α1
• Function-spacer-lipid constructs of Lewis and chimeric Lewis/ABH glycans. Synthesis and use in serological studies
  作者：Ivan M. Ryzhov、Elena Yu. Korchagina、Alexander B. Tuzikov、Inna S. Popova、Tatiana V. Tyrtysh、Galina V. Pazynina、Stephen M. Henry、Nicolai V. Bovin

  DOI：10.1016/j.carres.2016.09.016

  日期：2016.11

  Seven lipophilic constructs containing Lewis (Le(a), Le(b), Le(y)) or chimeric Lewis/ABH (ALe(b), BLe(b), ALe(y), BLe(y)) glycans were obtained starting from corresponding oligosaccharides in form of 3-aminopropyl glycosides. ALe(b) and BLe(b) pentasaccharides were synthesized via [3 + 1] blockwise approach. The constructs (neoglycolipids, or FSLs) were inserted in erythrocyte membrane, and obtained "kodecytes" were used to map the immunochemical specificity of historical and contemporary monoclonal and polyclonal blood group system Lewis reagents. (C) 2016 Published by Elsevier Ltd.