[4-(4-hydroxy-phenoxy)-3,5-diiodo-phenyl]-acetic acid hydrazide | 92160-59-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-(4-hydroxy-phenoxy)-3,5-diiodo-phenyl]-acetic acid hydrazide
• 英文别名: [4-(4-Hydroxy-phenoxy)-3,5-dijod-phenyl]-essigsaeure-hydrazid
• CAS: 92160-59-3
• 化学式: C₁₄H₁₂I₂N₂O₃
• 分子量: 510.07
• InChiKey: IKHGEIDCVGBOHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.93
• 重原子数：
  21.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  84.58
• 氢给体数：
  3.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  [4-(4-hydroxy-phenoxy)-3,5-diiodo-phenyl]-acetic acid hydrazide 在 盐酸 、 ammonium hydroxide 、 碘 、 溶剂黄146 、 丙酮 、 sodium nitrite 作用下， 生成 N-{[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-acetyl}-glycine
  参考文献：
  名称：

  Addition of dextrose 3.5% to intrathecal sufentanil for labour analgesia reduces pruritus

  摘要：

  Purpose: To determine whether the addition of a low concentration (3.5%) of dextrose would minimize pruritus while maintaining the quality of analgesia.Methods: In a double blind study 48 parturients in early labour were randomized to one of two study groups: dextrose (Dex, n = 24; 10 mug sufentanil in dextrose 3.5%), or normal saline (NS, n = 24; 10 mug sufentanil in normal saline). Parturients received the study drug as the intrathecal injection of the combined spinal-epidural (CSE) technique for labour analgesia. Duration and degree of analgesia were measured until epidural analgesia was initiated or delivery of the baby. The intensity and distribution (above T-6, T-6-L-1, and below L-1) of pruritus were measured at five minute intervals during first 25 min after injection.Results: Quality and duration of analgesia did not differ between groups, but the overall incidence of pruritus was less in the Dex group (88% vs 42%, P = 0.001). Within each region, the incidence of pruritus was less in the Dex group. In patients who had pruritus, for the Dex group, the incidence of pruritus in the upper region (>T6) was lower than the NS group. There was no difference in the lower regions.Conclusion: The addition of dextrose 3.5% to intrathecal sufentanil reduced the incidence of pruritus without affecting the duration or quality of analgesia in parturients in early labour. The distribution of pruritus in the Dex group was limited to below T-6 suggesting that pruritus to intrathecal sufentanil is mediated at the spinal level.

  DOI：

  10.1007/bf03019864
• 作为产物：
  描述：

  3,5-二碘-THYRO乙酸 在 盐酸 、 乙醇 、 一水合肼 作用下， 反应 2.0h， 生成 [4-(4-hydroxy-phenoxy)-3,5-diiodo-phenyl]-acetic acid hydrazide
  参考文献：
  名称：

  Addition of dextrose 3.5% to intrathecal sufentanil for labour analgesia reduces pruritus

  摘要：

  Purpose: To determine whether the addition of a low concentration (3.5%) of dextrose would minimize pruritus while maintaining the quality of analgesia.Methods: In a double blind study 48 parturients in early labour were randomized to one of two study groups: dextrose (Dex, n = 24; 10 mug sufentanil in dextrose 3.5%), or normal saline (NS, n = 24; 10 mug sufentanil in normal saline). Parturients received the study drug as the intrathecal injection of the combined spinal-epidural (CSE) technique for labour analgesia. Duration and degree of analgesia were measured until epidural analgesia was initiated or delivery of the baby. The intensity and distribution (above T-6, T-6-L-1, and below L-1) of pruritus were measured at five minute intervals during first 25 min after injection.Results: Quality and duration of analgesia did not differ between groups, but the overall incidence of pruritus was less in the Dex group (88% vs 42%, P = 0.001). Within each region, the incidence of pruritus was less in the Dex group. In patients who had pruritus, for the Dex group, the incidence of pruritus in the upper region (>T6) was lower than the NS group. There was no difference in the lower regions.Conclusion: The addition of dextrose 3.5% to intrathecal sufentanil reduced the incidence of pruritus without affecting the duration or quality of analgesia in parturients in early labour. The distribution of pruritus in the Dex group was limited to below T-6 suggesting that pruritus to intrathecal sufentanil is mediated at the spinal level.

  DOI：

  10.1007/bf03019864