| 1269500-83-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1269500-83-5
• 化学式: C₃₅H₃₈O₁₁
• 分子量: 634.68
• InChiKey: ZSADNFALYQNZBT-QNKNHBCRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.52
• 重原子数：
  46.0
• 可旋转键数：
  16.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  143.89
• 氢给体数：
  1.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  、 (2-methyl-5-tert-butylphenyl) 2,3,6-tri-O-benzoyl-5-O-levulinyl-1-thio-β-D-galactofuranoside 在 N-溴代丁二酰亚胺(NBS) 、 三氟甲磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以60%的产率得到
  参考文献：
  名称：

  Synthetic biotinylated tetra β(1→5) galactofuranoside for in vitro aspergillosis diagnosis

  摘要：

  The synthesis of a tetra beta(1 -> 5) galactofuranoside was achieved using a thioglycoside donor with a methyl tert-butyl phenyl thio leaving group. This tetrasaccharide was conjugated to biotin and validated as antigen with the monoclonal antibody used for clinical detection of Aspergillus fumigatus galactomannan on streptavidin-coated microplates. Then we have shown its ability to detect antibodies associated with A. fumigatus induced disease by using sera from patients with Allergic broncho-pulmonary aspergillosis (ABPA) and correlated the results of antibody detection with those gained with a commercially available diagnostic test. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.10.062
• 作为产物：
  描述：

  (2S,3S,4R,5R)-2-((R)-2-(benzoyloxy)-1-((4-oxopentanoyl)oxy)ethyl)-5-((6-ethoxy-6-oxohexyl)oxy)tetrahydrofuran-3,4-diyl dibenzoate 在 吡啶 、 一水合肼 、 溶剂黄146 作用下， 反应 0.5h， 以67%的产率得到
  参考文献：
  名称：

  Synthetic biotinylated tetra β(1→5) galactofuranoside for in vitro aspergillosis diagnosis

  摘要：

  The synthesis of a tetra beta(1 -> 5) galactofuranoside was achieved using a thioglycoside donor with a methyl tert-butyl phenyl thio leaving group. This tetrasaccharide was conjugated to biotin and validated as antigen with the monoclonal antibody used for clinical detection of Aspergillus fumigatus galactomannan on streptavidin-coated microplates. Then we have shown its ability to detect antibodies associated with A. fumigatus induced disease by using sera from patients with Allergic broncho-pulmonary aspergillosis (ABPA) and correlated the results of antibody detection with those gained with a commercially available diagnostic test. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.10.062