8-(4-hydroxyphenyl)-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one | 1311968-94-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 8-(4-hydroxyphenyl)-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
• CAS: 1311968-94-1
• 化学式: C₁₅H₁₀N₂O₄
• 分子量: 282.255
• InChiKey: OMFVSTQXFWOBMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  8-(4-methoxyphenyl)-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以91%的产率得到8-(4-hydroxyphenyl)-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
  参考文献：
  名称：

  Suzuki–Miyaura reactions of the soluble guanylate cyclase inhibitor NS2028: a non-product specific route to C-8 substituted analogues

  摘要：

  Both soluble guanylate cyclase (sGC) inhibitors ODQ 1 and NS2028 2 are synthesized via improved protocols. In the former case treating 3,4-dihydroquinoxalin-2(1H)-one oxime 8, which can be prepared in two steps from 1,2-benzenediamine, with 1,1'-carbonyldiimidazole (CDI) gives the dihydro-ODQ 10 that in the presence of KMnO4 oxidises to give ODQ 1 in an overall yield of 46% starting from 1,2-benzenediamine. In the latter case, the synthesis affords NS2028 2 from 2-amino-4-bromophenol 3 in three steps with an overall yield of 85% and avoids the need for chromatography. Furthermore, Suzuki-Miyaura reaction conditions are described that enable the preparation of 8-aryl and 8-heteroaryl derivatives of NS2028 directly from NS2028 2. Finally, demethylation of the 8-(methoxyphenyl) substituted analogues afforded the 8-(hydroxyphenyl) derivatives 40-42. All new products are fully characterised. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.04.003