(1S,3S,6S,9S,12S,14R,16R,18S,20S,22R,23R,25S,26S,27R,31R,34S,36R,37S,38R,40R,41S)-22-[tert-butyl(dimethyl)silyl]oxy-23-(3-dimethoxyphosphoryl-2-oxopropyl)-14,26-dimethyl-8,15-dimethylidene-2,19,24,28,35,39,42,44,45,46-decaoxadecacyclo[29.9.2.13,37.13,38.16,9.112,16.018,27.020,25.034,41.036,40]hexatetracontan-29-one | 1159006-52-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S,3S,6S,9S,12S,14R,16R,18S,20S,22R,23R,25S,26S,27R,31R,34S,36R,37S,38R,40R,41S)-22-[tert-butyl(dimethyl)silyl]oxy-23-(3-dimethoxyphosphoryl-2-oxopropyl)-14,26-dimethyl-8,15-dimethylidene-2,19,24,28,35,39,42,44,45,46-decaoxadecacyclo[29.9.2.13,37.13,38.16,9.112,16.018,27.020,25.034,41.036,40]hexatetracontan-29-one
• CAS: 1159006-52-6
• 化学式: C₅₁H₇₉O₁₆PSi
• 分子量: 1007.24
• InChiKey: PRCPSXHZGOHZHU-HOBDNQFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.68
• 重原子数：
  69
• 可旋转键数：
  9
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  171
• 氢给体数：
  0
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  methyl 2-((2R,3R,5S,6S)-3,5-bis(tert-butyldimethylsilyloxy)-6-((2S,6S,7S)-7-(4-methoxybenzyloxy)-6-methyl-4,8-dioxooctan-2-yl)tetrahydro-2H-pyran-2-yl)acetate 、 (1S,3S,6S,9S,12S,14R,16R,18S,20S,22R,23R,25S,26S,27R,31R,34S,36R,37S,38R,40R,41S)-22-[tert-butyl(dimethyl)silyl]oxy-23-(3-dimethoxyphosphoryl-2-oxopropyl)-14,26-dimethyl-8,15-dimethylidene-2,19,24,28,35,39,42,44,45,46-decaoxadecacyclo[29.9.2.13,37.13,38.16,9.112,16.018,27.020,25.034,41.036,40]hexatetracontan-29-one 在 18-冠醚-6 、 potassium carbonate 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以83%的产率得到
  参考文献：
  名称：

  Jackson, Katrina L.; Henderson, James A.; Motoyoshi, Hajime, Angewandte Chemie - International Edition, 2009, vol. 48, p. 2346 - 2350

  摘要：

  DOI：
• 作为产物：
  描述：

  、 dimethyl diazomethylphosphonate 在 tin(ll) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 25.0h， 以74%的产率得到(1S,3S,6S,9S,12S,14R,16R,18S,20S,22R,23R,25S,26S,27R,31R,34S,36R,37S,38R,40R,41S)-22-[tert-butyl(dimethyl)silyl]oxy-23-(3-dimethoxyphosphoryl-2-oxopropyl)-14,26-dimethyl-8,15-dimethylidene-2,19,24,28,35,39,42,44,45,46-decaoxadecacyclo[29.9.2.13,37.13,38.16,9.112,16.018,27.020,25.034,41.036,40]hexatetracontan-29-one
  参考文献：
  名称：

  Jackson, Katrina L.; Henderson, James A.; Motoyoshi, Hajime, Angewandte Chemie - International Edition, 2009, vol. 48, p. 2346 - 2350

  摘要：

  DOI：