hydroleptosphol | 1135619-16-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: hydroleptosphol
• 英文别名: (4R,5R,6R,7R,10R)-10-[(E,3R,5R)-3,5-dimethylhept-1-enyl]-3,4,6,7-tetrahydroxy-3-methyl-2-oxaspiro[4.5]dec-8-en-1-one
• CAS: 1135619-16-7
• 化学式: C₁₉H₃₀O₆
• 分子量: 354.444
• InChiKey: YREGLMQCOGERBX-PNBHOSHPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  hydroleptosphol 以 氘代氯仿 为溶剂， 生成 spiroleptosphol B
  参考文献：
  名称：

  Four analogues of spiroleptosphol isolated from Leptosphaeria doliolum

  摘要：

  Spiroleptosphol B (2), spiroleptosphol C (3), norleptosphol C (4) and hydroleptosphol (5) were isolated from ascomycete Leptosphaeria doliolum. Detailed H-1 and C-13 NMR spectral analyses revealed these were structural analogues of spiroleptosphol (1) which we have recently isolated from the same fungi. Spiroleptosphol B (2) carried an unprecedent 5,3-dioxatricyclo[4.4.0.1(1.4)] undecane framework in place of the spirobicyclo ring system of 1. Spiroleptosphol C (3) was a 17-(R)-hydroxy derivative of 1. Norleptosphol C (4) was deduced to be the monocyclic structure biosynthetically resulted by decarboxylation from 3. Although 5 gave broaden H-1 NMR spectrum, it was gradually transformed to 2 which suggested being a hydrolysate of 1. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.12.004