1,4,6-trimethylpyrazolo[3,4-b]pyridyl-3-azide | 1013760-49-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 1,4,6-trimethylpyrazolo[3,4-b]pyridyl-3-azide
• 英文别名: 3-Azido-1,4,6-trimethylpyrazolo[3,4-b]pyridine
• CAS: 1013760-49-0
• 化学式: C₉H₁₀N₆
• 分子量: 202.219
• InChiKey: SUDDHUGAAOSHPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  45.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4,6-trimethylpyrazolo[3,4-b]pyridyl-3-azide 、 乙酰丙酮 在 三乙胺 作用下， 以 乙腈 为溶剂， 以81%的产率得到3-(4-acetyl-5-methyl-1,2,3-triazol-1-yl)-1,4,6-trimethylpyrazolo[3,4-b]pyrimidine
  参考文献：
  名称：

  Synthesis and transformations of substituted 4,6-dimethylpyrazolo[3,4-b]pyridyl-3-azides and -sulfonyl chlorides

  摘要：

  Diazotization of the amino group of 3-amino-4,6-dimethylpyrazolo[3,4-b]pyrimidines and subsequent replacement of the diazo group in the formed diazonium chlorides by an azide group gave the corresponding 3-azido derivatives. Their reactions with active methylene compounds have been studied. Substitution of the diazo group by a sulfo group gave the related 4,6-dimethylpyrazolo-[3,4-b]pyridyl-3-sulfonyl chlorides and sulfonylamides.

  DOI：

  10.1007/s10593-009-0169-y
• 作为产物：
  描述：

  1,4,6-三甲基-3-氨基吡唑并[3,4-B]吡啶 在 盐酸 、 sodium nitrite 、 sodium azide 作用下， 以 水 为溶剂， 以84%的产率得到1,4,6-trimethylpyrazolo[3,4-b]pyridyl-3-azide
  参考文献：
  名称：

  Synthesis and transformations of substituted 4,6-dimethylpyrazolo[3,4-b]pyridyl-3-azides and -sulfonyl chlorides

  摘要：

  Diazotization of the amino group of 3-amino-4,6-dimethylpyrazolo[3,4-b]pyrimidines and subsequent replacement of the diazo group in the formed diazonium chlorides by an azide group gave the corresponding 3-azido derivatives. Their reactions with active methylene compounds have been studied. Substitution of the diazo group by a sulfo group gave the related 4,6-dimethylpyrazolo-[3,4-b]pyridyl-3-sulfonyl chlorides and sulfonylamides.

  DOI：

  10.1007/s10593-009-0169-y