methyl 2,3,4-tri-O-acetyl-6-O-methyl-α-D-mannopyranoside | 28140-05-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2,3,4-tri-O-acetyl-6-O-methyl-α-D-mannopyranoside
• 英文别名: Methyl-2,3,4-tri-O-acetyl-6-O-methyl-α-D-mannopyranosid；[(2R,3R,4S,5S,6S)-4,5-diacetyloxy-6-methoxy-2-(methoxymethyl)oxan-3-yl] acetate
• CAS: 28140-05-8
• 化学式: C₁₄H₂₂O₉
• 分子量: 334.323
• InChiKey: HRFADBZDDVTPAQ-DGTMBMJNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  重氮甲烷 、 [4,5-diacetyloxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl] acetate 在 三氟化硼乙醚 作用下， 生成 methyl 2,3,4-tri-O-acetyl-6-O-methyl-α-D-mannopyranoside 、 Acetic acid (2R,3S,4S)-4-acetoxy-2-((R)-1-acetoxy-2-methoxy-ethyl)-5-methoxy-tetrahydro-furan-3-yl ester 、 methyl 2,3,6-tri-O-acetyl-4-O-methyl-D-mannoside 、 methyl 2,3,4-tri-O-acetyl-6-O-methyl-β-D-mannopyranoside
  参考文献：
  名称：

  Evidence of acetyl migration during the methylation of methyl 2,3,4-tri-O-acetyl-d-mannose with diazomethaneboron trifluoride etherate

  摘要：

  DOI：

  10.1016/0008-6215(91)89025-b

文献信息

• Methylation of methyl α-d-hexopyranosides with diazo-methane in the presence of a small amount of water
  作者：Yuko Inoue、Kinzo Nagasawa

  DOI：10.1016/0008-6215(87)80024-1

  日期：1987.11

  Abstract The long-time reduction of methyl α- d -gluco-, α- d -manno-, and α- d -galactopyranosides with excess diazomethane-diethyl ether at 25° in the presence of water gave all partially methylated methyl α- d -hexopyranosides which differ in number and position of methyl substitution. The presence of electrolytes, such as potassium or sodium phosphate, in the reaction medium enhanced the degree of methylation

  摘要在水存在下，用过量的重氮甲烷-二乙醚在25°下长时间还原甲基α-d-葡萄糖-，α-d-甘露糖和α-d-吡喃半乳糖苷，所有部分甲基化的甲基α-d -甲基吡喃糖苷的数目和位置不同。反应介质中电解质（例如磷酸钾或磷酸钠）的存在增强了甲基化的程度，从而导致优先形成甲基α-d-己基吡喃糖苷的三-O-甲基衍生物。
• NOVEL MANNOPYRANOSIDE DERIVATIVES WITH ANTICANCER ACTIVITY
  申请人：Montero Jean-Louis

  公开号：US20120269903A1

  公开（公告）日：2012-10-25

  The present invention relates to mannopyranoside-derived compounds and to the use thereof as medicaments, in particular in the treatment of cancer diseases, and also to the method for preparing same and to pharmaceutical compositions comprising such compounds. Medical devices surface-treated with mannopyranoside-derived compounds according to the invention also form part of the invention.

  本发明涉及来源于甘露聚糖苷衍生物的化合物及其作为药物的用途，特别是在治疗癌症疾病方面的用途，还涉及制备该化合物的方法以及包含这些化合物的药物组合物。根据本发明用甘露聚糖苷衍生物处理表面的医疗器械也属于本发明的一部分。
• Hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them
  申请人：LES LABORATOIRES SERVIER

  公开号：US10322131B2

  公开（公告）日：2019-06-18

  Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, A and n are as defined in the description.

  式(I)化合物： 其中 R1、R2、R3、R4、R5、R6、R7、R8、R14、A 和 n 如说明中所定义。
• HYDROXYACID DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：LES LABORATOIRES SERVIER

  公开号：US20180185369A1

  公开（公告）日：2018-07-05

  Compounds of formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 14 , A and n are as defined in the description.