2-bromohexadecanal | 136705-33-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-bromohexadecanal
• 英文别名: 2-Bromopalmitaldehyde
• CAS: 136705-33-4
• 化学式: C₁₆H₃₁BrO
• 分子量: 319.326
• InChiKey: UNCLDPYYBFIMJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  硝基乙酸乙酯 、 2-bromohexadecanal 在 aluminum oxide 作用下， 以 neat (no solvent) 为溶剂， 反应 23.0h， 生成 (4S,5S)-4-Hydroxy-2-oxy-5-tetradecyl-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester 、 (4S,5R)-4-Hydroxy-2-oxy-5-tetradecyl-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Stereocontrolled synthesis of 3-(ethoxycarbonyl)-4-hydroxy-2-isoxazoline-2-oxides. A new approach to the synthesis of 4-hydroxylated 2-isoxazolines

  摘要：

  Treatment of 2-bromo aldehydes and ethyl nitroacetate with alumina without solvent, or in solution with a tertiary base, at room temperature gives the diastereoisomeric title compounds in fair yields by a tandem nitroaldol reaction-cyclization sequence opening a new route for the preparation of trans and cis 4-hydroxylated 2-isoxazolines in a predictable way.

  DOI：

  10.1021/jo00022a005

文献信息

• Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis
  申请人：CONCIEVALVE LLC

  公开号：US10058630B2

  公开（公告）日：2018-08-28

  Methods for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall are disclosed. In one aspect the method includes providing a bioprosthetic heart valve mounted on an elastical stent; treating the bioprosthetic heart valve with a tissue fixative; coating the stent and the bioprosthetic valve with a coating composition including one or more therapeutic agents; implanting the bioprosthetic valve into the vessel in a diseased natural valve site; eluting the coating composition from the bioprosthetic valve; and inhibiting stenosis, obstruction and/or calcification of the bioprosthetic heart valve by preventing the attachment of stem cells to the bioprosthetic heart valve, the stem cells circulating external and proximate to the bioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.

  本发明公开了抑制心脏瓣膜植入有壁血管后狭窄、阻塞和/或钙化的方法。在一个方面，该方法包括提供安装在弹性支架上的生物人工心脏瓣膜；用组织固定剂处理生物人工心脏瓣膜；用包括一种或多种治疗剂的涂层组合物涂覆支架和生物人工心脏瓣膜；将生物人工心脏瓣膜植入病变的天然瓣膜部位的血管中；从生物人工心脏瓣膜中洗脱涂层组合物；通过激活(i)循环干细胞中、(ii)覆盖生物人工心脏瓣膜组织的内皮细胞衬里中、(iii)或两者中的一氧化氮的产生，防止干细胞附着到生物人工心脏瓣膜、干细胞在生物人工心脏瓣膜外部和近旁循环，从而抑制生物人工心脏瓣膜的狭窄、阻塞和/或钙化。
• Diagnosis of leukocyte-mediated disease and halogen gas exposure
  申请人：Saint Louis University

  公开号：US10983137B2

  公开（公告）日：2021-04-20

  Described are glutathione adducts of fatty aldehydes (FALD-GSH) and methods useful in the detection of FALD-GSH in the identification of pathologies associated with leukocyte-mediated disease conditions, including eosinophil and neutrophil activation. Thus, the present disclosure provides methods of diagnosing a subject as having or being at risk of developing a leukocyte-mediated disease (LMD) comprising (a) detecting the level of glutathione adducts of 2-halofatty aldehydes (FALD-GSH) in a sample; (b) comparing the amount of FALD-GSH with a control or standard reflective of diseased and/or healthy levels of FALD-GSH; and (c) diagnosing the subject as having or being at risk of developing LMD if the level of FALD-GSH in the sample is higher than the control or standard.

  本发明描述了脂肪醛的谷胱甘肽加合物（FALD-GSH）和检测 FALD-GSH 的方法，这些方法可用于鉴定与白细胞介导的疾病（包括嗜酸性粒细胞和中性粒细胞活化）相关的病理学。因此，本公开提供了诊断受试者患有白细胞介导的疾病（LMD）或有患该病风险的方法，包括 (a) 检测样本中 2-脂肪醛的谷胱甘肽加合物（FALD-GSH）的水平；(b) 将 FALD-GSH 的含量与反映 FALD-GSH 患病和/或健康水平的对照或标准进行比较；以及 (c) 如果样本中的 FALD-GSH 水平高于对照或标准，则诊断受试者患有 LMD 或有患 LMD 的风险。
• Physiologically active substance FA-5859, its derivative; their production and antidiabetic agents containing said compounds
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0080695B1

  公开（公告）日：1985-04-17
• Verfahren zur Herstellung von Thiophenen aus alpha-Methylenketonen im Eintopfverfahren und mittels des Verfahrens hergestellte neue anellierte Thiophene
  申请人：Von der Haar-Czogalla, Rita

  公开号：EP0275524B1

  公开（公告）日：1991-05-15
• METHODS FOR INHIBITING STENOSIS, OBSTRUCTION, OR CALCIFICATION OF A STENTED HEART VALVE OR BIOPROSTHESIS
  申请人：Concievalve LLC

  公开号：EP3474780A1

  公开（公告）日：2019-05-01