4-chlorocarbonyl-2,6-dimethylmorpholine | 1601099-54-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-chlorocarbonyl-2,6-dimethylmorpholine
• 英文别名: 2,6-Dimethylmorpholine-4-carbonyl chloride
• CAS: 1601099-54-0
• 化学式: C₇H₁₂ClNO₂
• 分子量: 177.631
• InChiKey: ROBIABICEDEGND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-chlorocarbonyl-2,6-dimethylmorpholine 在 一水合肼 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 36.0h， 生成 2-(2,6-dimethylmorpholine-4-carbonyl)-N-(4-methoxy-3H-imidazo[4,5-c]pyridin-2-yl)hydrazine-1-carbothioamide
  参考文献：
  名称：

  [EN] IMIDAZOPYRIDINE AND OXAZOLOPYRIDINE DERIVATIVES AND ANALOGS THEREOF, METHODS OF PREPARATION THEREOF, METHODS OF HIF-1/2A PATHWAY INHIBITION, AND INDUCTION OF FERROPTOSIS
  [FR] DÉRIVÉS D'IMIDAZOPYRIDINE ET D'OXAZOLOPYRIDINE ET LEURS ANALOGUES, LEURS PROCÉDÉS DE PRÉPARATION, PROCÉDÉS D'INHIBITION DE LA VOIE HIF-1/2A ET INDUCTION DE LA FERROPTOSE

  摘要：

  Novel substituted imidazopyridine and oxazolopyridine compounds that are useful as inhibitors of HIF-1α and HIF-2α and inducers of ferroptosis through perturbations in iron metabolism, synthetic methods for making said compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions to treat disorders associated with dysfunction of HIF-1/2α or iron metabolism.

  公开号：

  WO2023234970A1
• 作为产物：
  描述：

  2,6-二甲基吗啉 在 三光气 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 4-chlorocarbonyl-2,6-dimethylmorpholine
  参考文献：
  名称：

  [EN] IMIDAZOPYRIDINE AND OXAZOLOPYRIDINE DERIVATIVES AND ANALOGS THEREOF, METHODS OF PREPARATION THEREOF, METHODS OF HIF-1/2A PATHWAY INHIBITION, AND INDUCTION OF FERROPTOSIS
  [FR] DÉRIVÉS D'IMIDAZOPYRIDINE ET D'OXAZOLOPYRIDINE ET LEURS ANALOGUES, LEURS PROCÉDÉS DE PRÉPARATION, PROCÉDÉS D'INHIBITION DE LA VOIE HIF-1/2A ET INDUCTION DE LA FERROPTOSE

  摘要：

  Novel substituted imidazopyridine and oxazolopyridine compounds that are useful as inhibitors of HIF-1α and HIF-2α and inducers of ferroptosis through perturbations in iron metabolism, synthetic methods for making said compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions to treat disorders associated with dysfunction of HIF-1/2α or iron metabolism.

  公开号：

  WO2023234970A1

文献信息

• Diacyl indazole derivatives as lipase and phospholipase inhibitors
  申请人：Zoller Gerhard

  公开号：US20080287448A1

  公开（公告）日：2008-11-20

  The invention relates to diacyl indazole derivatives of general formulae (I) or (II) and to the pharmaceutically acceptable salts thereof: Wherein X, R1 and R2 are as defined herein. The invention also relates to the use of these compounds as pharmaceutical products.

  该发明涉及一般式(I)或(II)的二酰基吲唑衍生物以及其药用可接受的盐：其中X，R1和R2如本文所定义。该发明还涉及将这些化合物用作药物产品。
• [EN] BENZAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES<br/>[FR] COMPOSÉS DE BENZAMIDE ET LEUR UTILISATION EN TANT QU'HERBICIDES
  申请人：BASF SE

  公开号：WO2019016385A1

  公开（公告）日：2019-01-24

  The present invention relates to benzamide compounds of the formula (I) and the N-oxides and salts thereof and to compositions comprising the same. The variables are as defined in the claims and the description. The invention also relates to the use of the benzamide compounds or of the compositions comprising such compounds for controlling unwanted vegetation. Furthermore, the invention relates to methods of applying such compounds.

  本发明涉及公式（I）的苯甲酰胺化合物及其N-氧化物和盐，以及包含它们的组合物。变量如权利要求和说明书中所定义。本发明还涉及使用苯甲酰胺化合物或包含这种化合物的组合物来控制不良植被。此外，本发明还涉及应用这种化合物的方法。
• Process for the preparation of 1,4-disubstituted-5(4H)-tetrazolinones
  申请人：NIHON BAYER AGROCHEM K.K.

  公开号：EP0646577A1

  公开（公告）日：1995-04-05

  1,4-Disubstituted-5(4H)-tetrazolinones of the formula (I) (wherein R¹, R² and R³ have the meanings given in the specification), which are known to be useful as herbicides, can be obtained in very good yields by reacting the corresponding 1-substituted-5(4H)-tetrazolinones with the corresponding carbamoyl chlorides in the presence of 4-dimethylaminopyridine.

  式 (I) 的 1,4-二取代-5(4H)-四唑啉酮 将相应的 1-取代-5(4H)-四唑啉酮与相应的氨基甲酰氯在 4-二甲氨基吡啶存在下进行反应，可获得收率极高的 1,4-二取代-5(4H)-四唑啉酮，该化合物已知可用作除草剂（其中 R¹、R² 和 R³ 的含义见说明书）。
• DIACYLINDAZOL-DERIVATE ALS INHIBITOREN VON LIPASEN UND PHOSPHOLIPASEN
  申请人：sanofi-aventis

  公开号：EP1937648A1

  公开（公告）日：2008-07-02
• US5767286A
  申请人：——

  公开号：US5767286A

  公开（公告）日：1998-06-16