(S)-5-Benzyl-3-ethyl-5-(3-hydroxy-propyl)-5H-furan-2-one | 210684-78-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S)-5-Benzyl-3-ethyl-5-(3-hydroxy-propyl)-5H-furan-2-one
• 英文别名: (5S)-5-benzyl-3-ethyl-5-(3-hydroxypropyl)furan-2-one
• CAS: 210684-78-9
• 化学式: C₁₆H₂₀O₃
• 分子量: 260.333
• InChiKey: AAEOWPVPBYKERH-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-5-Benzyl-3-ethyl-5-(3-hydroxy-propyl)-5H-furan-2-one 在 silica gel 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 以72%的产率得到3-[(2S)-2-benzyl-4-ethyl-5-oxofuran-2-yl]propanal
  参考文献：
  名称：

  Asymmetric synthesis and fragmentation reactions of 2-alkyl- and 2, 4-dialkyl-3-iodo-1-oxocyclohexan-2, 4-carbolactones. Single enantiomer preparation of Δα, β-butenolides, 2-alkyl-4-hydroxy-2-cyclohexen-1-ones and butyrolactones

  摘要：

  Fragmentation reactions of keto iodolactones 4 provide access to butenolides 5, 2-alkyl-4-hydroxy-2-cyclohexen-1-ones 6, and butyrolactones 9. Delta(alpha,beta)-Butenolides 5e and 5f were converted to heterocycles 14-16 by way of intramolecular cycloaddition reactions. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00785-0
• 作为产物：
  描述：

  (2'S,6R)-4-benzyl-6-ethyl-1-methoxy-6-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]-1,4-cyclohexadiene 在 盐酸 、 lithium hydroxide 、 硼烷 、 碘 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 生成 (S)-5-Benzyl-3-ethyl-5-(3-hydroxy-propyl)-5H-furan-2-one
  参考文献：
  名称：

  Asymmetric synthesis and fragmentation reactions of 2-alkyl- and 2, 4-dialkyl-3-iodo-1-oxocyclohexan-2, 4-carbolactones. Single enantiomer preparation of Δα, β-butenolides, 2-alkyl-4-hydroxy-2-cyclohexen-1-ones and butyrolactones

  摘要：

  Fragmentation reactions of keto iodolactones 4 provide access to butenolides 5, 2-alkyl-4-hydroxy-2-cyclohexen-1-ones 6, and butyrolactones 9. Delta(alpha,beta)-Butenolides 5e and 5f were converted to heterocycles 14-16 by way of intramolecular cycloaddition reactions. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00785-0

文献信息

• Asymmetric synthesis and fragmentation reactions of 2-alkyl- and 2, 4-dialkyl-3-iodo-1-oxocyclohexan-2, 4-carbolactones. Single enantiomer preparation of Δα, β-butenolides, 2-alkyl-4-hydroxy-2-cyclohexen-1-ones and butyrolactones
  作者：Arthur G. Schultz、Mingshi Dai、Seock-Kyu Khim、Liping Pettus、Kshitij Thakkar

  DOI：10.1016/s0040-4039(98)00785-0

  日期：1998.6

  Fragmentation reactions of keto iodolactones 4 provide access to butenolides 5, 2-alkyl-4-hydroxy-2-cyclohexen-1-ones 6, and butyrolactones 9. Delta(alpha,beta)-Butenolides 5e and 5f were converted to heterocycles 14-16 by way of intramolecular cycloaddition reactions. (C) 1998 Elsevier Science Ltd. All rights reserved.