2-Methyl-3-oxo-s-triazolo<4,3-a>pyridin | 4231-60-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Methyl-3-oxo-s-triazolo<4,3-a>pyridin
• 英文别名: 2-methyl-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one；2-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-one
• CAS: 4231-60-1
• 化学式: C₇H₇N₃O
• 分子量: 149.152
• InChiKey: MTAUWGJDZIAUQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  35.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-肼吡啶 以 丙酮 为溶剂， 反应 2.0h， 生成 2-Methyl-3-oxo-s-triazolo<4,3-a>pyridin
  参考文献：
  名称：

  Synthesis of New Mesomeric Betaines Containing a Triazolopyridiniumolate System and Their Unexpected Function as Masked Isocyanates

  摘要：

  DOI：

  10.3987/com-99-8760

文献信息

• [EN] DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS<br/>[FR] INHIBITEURS DOUBLES DE NAV1.2/5HT2A POUR TRAITER DES TROUBLES DU SNC
  申请人：SUNOVION PHARMACEUTICALS INC

  公开号：WO2018026371A1

  公开（公告）日：2018-02-08

  Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.

  公开了化学式I的化合物，以及含有这些化合物的药物组合物。还公开了治疗患有神经系统或精神障碍的患者的方法。这些障碍包括抑郁症、躁郁症、疼痛、精神分裂症、强迫症、成瘾、社交障碍、注意力缺陷多动障碍、焦虑障碍、自闭症、认知障碍，或神经精神症状，如冷漠、抑郁、焦虑、精神病、攻击性、激动、冲动控制障碍，以及在神经系统疾病如阿尔茨海默病和帕金森病中的睡眠障碍。
• [EN] SUBSTITUTED 4-(1H~PYRAZOL-4.YL)BENZYL ANALOGUES AS POSITIVE ALLOSTERIC MODULATORS OF MACHR M1 RECEPTORS<br/>[FR] ANALOGUES DE 4-(LH-PYRAZOL-4-YL)BENZYLE SUBSTITUÉS EN TANT QUE MODULATEURS ALLOSTÉRIQUES POSITIFS DES RÉCEPTEURS M1 MACHR
  申请人：UNIV VANDERBILT

  公开号：WO2013106795A1

  公开（公告）日：2013-07-18

  In one aspect, the invention relates to substituted 4-(lH-pyrazol-4-yl)benzyl analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，该发明涉及取代的4-(1H-吡唑-4-基)苯甲基类似物化合物，其衍生物和相关化合物，这些化合物可用作肌胆碱受体M1 (mAChR M1)的正向变构调节剂；制备这些化合物的合成方法；包含这些化合物的药物组合物；以及利用这些化合物和组合物治疗与肌胆碱受体功能障碍相关的神经系统和精神疾病的方法。本摘要旨在作为在特定领域搜索的扫描工具，并不意在限制本发明。
• BICYCLOAMINE DERIVATIVES
  申请人：Ozaki Fumihiro

  公开号：US20090270369A1

  公开（公告）日：2009-10-29

  Compounds represented by formula (I) and pharmaceutically acceptable salts thereof have excellent sodium channel inhibitory action and are useful as therapeutic agents and analgesics for various kinds of neuralgia, neuropathy, epilepsy, insomnia, premature ejaculation and the like. wherein Q represents ethylene, etc., R 1 , R 2 and R 3 represent hydrogen, etc., X 1 represents C 1-6 alkylene, etc., X 2 represents C 1-6 alkylene, etc., A 1 represents a 5- to 6-membered heterocyclic group, etc., and A 2 represents C 6-14 aryl, etc.

  由式(I)表示的化合物及其药学上可接受的盐具有出色的钠通道抑制作用，并可用作治疗剂和各种神经痛、神经病、癫痫、失眠、早泄等的镇痛剂。其中Q代表乙烯等，R1、R2和R3代表氢等，X1代表C1-6烷基等，X2代表C1-6烷基等，A1代表5-至6-成员杂环基团等，A2代表C6-14芳基等。
• IMIDAZO[1,2-a]PYRIDINE COMPOUNDS
  申请人：SUNOVION PHARMACEUTICALS INC.

  公开号：US20130289013A1

  公开（公告）日：2013-10-31

  Imidazo[1,2-a]pyridines are disclosed. Compounds of the invention are useful therapeutic agents and their inclusion in pharmaceutical formulations and use in methods of treatment are disclosed.

  本发明公开了咪唑并[1,2-a]吡啶类化合物。本发明的化合物是有用的治疗剂，公开了它们在制药配方中的包含以及在治疗方法中的使用。
• BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS
  申请人：deCODE genetics ehf

  公开号：US20140301999A1

  公开（公告）日：2014-10-09

  The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula I: A particular embodiment is

  本发明涉及一类含有至少一个进一步环的联苯化合物。这些化合物是PDE4抑制剂，可用于治疗和预防中风、心肌梗死和心血管炎症性疾病和疾病。这些化合物的一般式为I：其中一种特定的实施形式为