6(R)-[2-[8(S)-(2,2-dimethylbutyryloxy)-2(S)-methyl-5(R)-dibenzylaminocarbonyloxy-6(R)-methyl-1,2,3,4,4a(R),5,6, 7,8,8a(R)-decahydronaphthyl-1(S)]ethyl]-4(R) tert-butyldiphenylsilyloxy-3,4,5,6-tetrahydro-2H-pyran-2-one | 127343-22-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 6(R)-[2-[8(S)-(2,2-dimethylbutyryloxy)-2(S)-methyl-5(R)-dibenzylaminocarbonyloxy-6(R)-methyl-1,2,3,4,4a(R),5,6, 7,8,8a(R)-decahydronaphthyl-1(S)]ethyl]-4(R) tert-butyldiphenylsilyloxy-3,4,5,6-tetrahydro-2H-pyran-2-one
• 英文别名: [(1S,3R,4R,4aR,7S,8S,8aR)-8-[2-[(2R,4R)-4-[tert-butyl(diphenyl)silyl]oxy-6-oxooxan-2-yl]ethyl]-4-(dibenzylcarbamoyloxy)-3,7-dimethyl-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-1-yl] 2,2-dimethylbutanoate
• CAS: 127343-22-0
• 化学式: C₅₆H₇₃NO₇Si
• 分子量: 900.284
• InChiKey: XGBJKRNNKULAJZ-MCOBNUCMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.29
• 重原子数：
  65
• 可旋转键数：
  18
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  91.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  6(R)-[2-[8(S)-(2,2-dimethylbutyryloxy)-2(S)-methyl-5(R)-dibenzylaminocarbonyloxy-6(R)-methyl-1,2,3,4,4a(R),5,6, 7,8,8a(R)-decahydronaphthyl-1(S)]ethyl]-4(R) tert-butyldiphenylsilyloxy-3,4,5,6-tetrahydro-2H-pyran-2-one 、 四丁基氟化铵 生成 6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6(R)-dimethyl-5(R)-<<(dibenzylamino)carbonyl>oxy>-1,2,3,4,4a(R),5,6,7,8,8a(R)-decahydronaphthyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
  参考文献：
  名称：

  DUGGAN, MARK E.;ALBERTS, ALFRED W.;BOSTEDOR, RICK;CHAO, YU-SHENG;GERMERSH+, J. MED. CHEM., 34,(1991) N, C. 2489-2495

  摘要：

  DOI：
• 作为产物：
  描述：

  6(R)-[2-[8(S)-(2,2-dimethylbutyryloxy)-2(S)-methyl-5(R)-hydroxy-6(R)-methyl-1,2,3,4,4a(R),5,6,7,8,8a(R)-decahydronaphthyl-1(S)]ethyl]-4(R)-tert-butyldiphenylsilyloxy-3,4,5,6-tetrahydro-2H-pyran-2-one 、 光气 、 二苄胺 生成 6(R)-[2-[8(S)-(2,2-dimethylbutyryloxy)-2(S)-methyl-5(R)-dibenzylaminocarbonyloxy-6(R)-methyl-1,2,3,4,4a(R),5,6, 7,8,8a(R)-decahydronaphthyl-1(S)]ethyl]-4(R) tert-butyldiphenylsilyloxy-3,4,5,6-tetrahydro-2H-pyran-2-one
  参考文献：
  名称：

  DUGGAN, MARK E.;ALBERTS, ALFRED W.;BOSTEDOR, RICK;CHAO, YU-SHENG;GERMERSH+, J. MED. CHEM., 34,(1991) N, C. 2489-2495

  摘要：

  DOI：

文献信息

• DUGGAN, MARK E.;ALBERTS, ALFRED W.;BOSTEDOR, RICK;CHAO, YU-SHENG;GERMERSH+, J. MED. CHEM., 34,(1991) N, C. 2489-2495
  作者：DUGGAN, MARK E.、ALBERTS, ALFRED W.、BOSTEDOR, RICK、CHAO, YU-SHENG、GERMERSH+

  DOI：——

  日期：——