(1S,5R,6R,7R)-6-(3,3-ethylenedioxyoctyl)-7-tetrahydropyranyloxy-2-oxabicyclo[3.3.0]octan-3-one | 118565-79-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S,5R,6R,7R)-6-(3,3-ethylenedioxyoctyl)-7-tetrahydropyranyloxy-2-oxabicyclo[3.3.0]octan-3-one
• 英文别名: (3aR,4R,5R,6aS)-5-(oxan-2-yloxy)-4-[2-(2-pentyl-1,3-dioxolan-2-yl)ethyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
• CAS: 118565-79-0
• 化学式: C₂₂H₃₆O₆
• 分子量: 396.524
• InChiKey: SMRMYLQASZVLNJ-YNAZQSIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (1S,5R,6R,7R)-6-(3,3-ethylenedioxyoctyl)-7-tetrahydropyranyloxy-2-oxabicyclo[3.3.0]octan-3-one 、 (4-carboxybutyl)triphenylphosphonium bromide 生成 (Z)-7-[(1R,2R,3R,5S)-5-hydroxy-3-(oxan-2-yloxy)-2-[2-(2-pentyl-1,3-dioxolan-2-yl)ethyl]cyclopentyl]hept-5-enoic acid
  参考文献：
  名称：

  UEHNO, RYUDZO;UEHNO, TAKASI;OTA, TOMIO

  摘要：

  DOI：
• 作为产物：
  描述：

  (1S,5R,6R,7R)-6-(3,3-ethylenedioxyoctyl)-7-hydroxy-2-oxabicyclo[3.3.0]octan-3-one 生成 (1S,5R,6R,7R)-6-(3,3-ethylenedioxyoctyl)-7-tetrahydropyranyloxy-2-oxabicyclo[3.3.0]octan-3-one
  参考文献：
  名称：

  UEHNO, RYUDZO;UEHNO, TAKASI;OTA, TOMIO

  摘要：

  DOI：

文献信息

• 15-keto-prostaglandin compound for improvement of encephalic function
  申请人：K.K. Ueno Seiyaku Oyo Kenkyujo

  公开号：US05117042A1

  公开（公告）日：1992-05-26

  A method of treatment for improving encephalic function which comprises administering, to a subject in need of such treatment, a 15-keto-prostaglandin compound in an amount effective for improvement of encephalic function.

  一种用于改善脑功能的治疗方法，包括向需要此类治疗的受试者施用一种15-酮前列腺素化合物，其剂量有效地改善脑功能。
• Treatment of inflammation with 15-keto-prostaglandin compounds
  申请人：R-Tech Ueno, Ltd.

  公开号：US05346921A1

  公开（公告）日：1994-09-13

  A method of treatment of inflammatory diseases which comprises administering, to a subject in need of such treatment, an anti-inflammatorily effective amount of a 15-keto-prostaglandin compound.

  一种治疗炎症性疾病的方法，包括向需要此类治疗的受试者施用抗炎有效量的15-酮前列腺素化合物。
• Promotion of wound-healing with 15-keto-prostaglandin compounds
  申请人：R-Tech Ueno Ltd.

  公开号：US05252605A1

  公开（公告）日：1993-10-12

  A method for promoting healing of wound which comprises administering, to a subject in need of such treatment, a wound-healingly effective amount of a 15-ketoprostaglandin compound.

  一种促进伤口愈合的方法，包括向需要此类治疗的受试者施用15-酮前列腺素化合物的愈合有效剂量。
• Treatment of pancreatic disease with 15-keto-prostaglandin compounds
  申请人：K.K. Ueno Seiyaku Oyo Kenkyujo

  公开号：US05164415A1

  公开（公告）日：1992-11-17

  A method of treatment of pancreatic disease which comprises administering, to a subject in need of such treatment, a 15-keto-prostaglandin compound in an amount effective in treatment of pancreatic disease.

  一种治疗胰腺疾病的方法，包括向需要此类治疗的受试者施用一定量的15-酮前列腺素化合物，以有效治疗胰腺疾病。
• Use of 15-keto-prostaglandin compound for improvement of encephalic
  申请人：Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo

  公开号：US05426115A1

  公开（公告）日：1995-06-20

  A method of treatment for improving encephalic function which comprises administering, to a subject in need of such treatment, a 15-keto-prostaglandin compound in an amount effective for improvement of encephalic function.

  一种改善脑功能的治疗方法，包括向需要此类治疗的受试者施用15-酮前列腺素化合物，其剂量足以改善脑功能。