2,3-diamino-2,3-dideoxyglucose | 7687-95-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3-diamino-2,3-dideoxyglucose
• 英文别名: 2,3-diamino-2,3-dideoxy-D-glucopyranose；(3R,4R,5S,6R)-3,4-diamino-6-(hydroxymethyl)oxane-2,5-diol
• CAS: 7687-95-8
• 化学式: C₆H₁₄N₂O₄
• 分子量: 178.188
• InChiKey: VUBSFQDNXFFAPF-IVMDWMLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  122
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  silver 1,1-cyclobutanedicarboxylate 、 2,3-diamino-2,3-dideoxy-D-glucose platinum chloride 以 水 为溶剂， 生成 2,3-diamino-2,3-dideoxyglucose
  参考文献：
  名称：

  Platinum complexes of polyhydroxylated alkylamines and

  摘要：

  聚羟基烷胺和2-聚羟基烷基-1,2-二胺乙烷的铂配合物可用于诱导哺乳动物癌症的退缩和/或缓解。

  公开号：

  US04587331A1

文献信息

• Platinum complexes
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0186085A2

  公开（公告）日：1986-07-02

  Platinum complexes useful for inducing regression and/or palliation of cancer diseases in mammals

  可诱导哺乳动物癌症疾病消退和/或缓解的铂复合物
• 2,3-Diacetamido-2,3-dideoxy-d-mannuronic acid and its 2-imidazoline derivative: new acidic amino sugars from Pseudomonas aeruginosa O: 3a,d lipopolysaccharide
  作者：Yuriy A. Knirel、Evgeniy V. Vinogradov、Alexander S. Shashkov、Boris A. Dmitriev、Nikolay K. Kochetkov

  DOI：10.1016/s0008-6215(00)82229-6

  日期：1982.6
• TRANSITION METAL-BASED FUNCTIONAL MOIETIES FOR PREPARING CELL TARGETING CONJUGATES
  申请人：LINXIS B.V.

  公开号：US20200345862A1

  公开（公告）日：2020-11-05

  The disclosure relates to secondary functional moieties comprising a transition metal-based linker and a primary functional moiety bound thereto. The disclosure also relates to cell targeting conjugates comprising a linker of the invention. The disclosure further relates to a medicament comprising the cell targeting conjugate and to the use of the cell targeting conjugates in the diagnosis and treatment of cancer.
• METHODS FOR PREPARING CELL TARGETING CONJUGATES AND CONJUGATES OBTAINABLE BY SAID METHODS
  申请人：LINXIS B.V.

  公开号：US20210113712A1

  公开（公告）日：2021-04-22

  Methods for preparing a cell targeting conjugate, which conjugate comprises a cell binding moiety conjugated to a secondary functional moiety. The disclosure further relates to the cell targeting conjugates obtainable by the method, to a pharmaceutical composition comprising the conjugates and to the secondary functional moieties as such. The disclosure also relates to the use of the cell targeting conjugates in the treatment of cancer.
• US4587331A
  申请人：——

  公开号：US4587331A

  公开（公告）日：1986-05-06