1-(3-甲基-3-环戊烯-1-基)乙酮 | 34498-99-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(3-甲基-3-环戊烯-1-基)乙酮
• 英文名称: 1-Methyl-4-acetylcyclopenten
• 英文别名: 1-(3-Methylcyclopent-3-en-1-yl)ethanone
• CAS: 34498-99-2
• 化学式: C₈H₁₂O
• 分子量: 124.183
• InChiKey: KOCZKEDXXWAENL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(3-甲基-3-环戊烯-1-基)乙酮 生成 2-(3-methyl-cyclopent-3-enyl)-propan-2-ol
  参考文献：
  名称：

  PAYNE, G. B.;SOLOWAY, S. B.;POWELL, J. E.;ROMAN, S. A.;KOLLMEYER, W. D.

  摘要：

  DOI：
• 作为产物：
  描述：

  (1S,2R,5S,6R)-1,2,5-trimethyl-3,4,10-trioxatricyclo[4.2.1.12,5]decane 生成 1-(3-甲基-3-环戊烯-1-基)乙酮
  参考文献：
  名称：

  GRIESBAUM, KARL;KRIEGER-BECK, PETRA;BECK, JOHANNES, J. ORG. CHEM., 56,(1991) N2, C. 4005-4008

  摘要：

  DOI：

文献信息

• Rearrangements of 2,5-dimethyl-2-vinyl-2,3-dihydrofuran and related isomers
  作者：Sara J. Rhoads、Charles F. Brandenburg

  DOI：10.1021/ja00751a037

  日期：1971.11
• GRIESBAUM, KARL;KRIEGER-BECK, PETRA;BECK, JOHANNES, J. ORG. CHEM., 56,(1991) N2, C. 4005-4008
  作者：GRIESBAUM, KARL、KRIEGER-BECK, PETRA、BECK, JOHANNES

  DOI：——

  日期：——
• PAYNE, G. B.;SOLOWAY, S. B.;POWELL, J. E.;ROMAN, S. A.;KOLLMEYER, W. D.
  作者：PAYNE, G. B.、SOLOWAY, S. B.、POWELL, J. E.、ROMAN, S. A.、KOLLMEYER, W. D.

  DOI：——

  日期：——
• COOLING SENSATION AGENT COMPOSITION AND SENSORY STIMULATION AGENT COMPOSITION
  申请人：Ishida Kenya

  公开号：US20110117147A1

  公开（公告）日：2011-05-19

  The invention relates to a cooling sensation agent composition with a prolonged cool sensation effect comprising at least one compound selected from Formula (1) wherein each of A and B is a hydrogen atom or a hydrocarbon group which may have one or more substituents, in which A and B are not hydrogen atoms simultaneously, and the total number of carbon atoms in A and B is in the range of 6 to 18; and Formulae (2) to (4) wherein R1, R2, and R3 each represent a residue of an alcohol selected from 1-menthol, 1-isopulegol, 3-(1-menthoxy)propan-1,2-diol, 2-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol, 2-methyl-3-(1-menthoxy)propan-1,2-diol and para-menthan-3,8-diol), and R4 represents a residue of a branched or straight-chain, cyclic or linear, or saturated or unsaturated alcohol having 6 to 18 carbon atoms that may have one or more aromatic rings that may have a condensed ring and substituent groups such as hydroxyl and ether groups; and R6 represents a hydrocarbon group having 11 to 19 carbon atoms that may be branched and contain one or more unsaturated bonds. The invention also relates to a sensory stimulation agent composition comprising the cooling sensation agent composition; a flavor or fragrance composition, a beverage or food product, a perfume or cosmetic product, a toiletry product, a daily utensil product or grocery, a fiber, a fiber product, a cloth or a medicine comprising the cooling sensation agent composition or the sensory stimulation agent composition; a production method thereof; a cooling processing method of a fiber, fiber product or a cloth, comprising compounding the cooling sensation agent composition or the sensory stimulation agent composition; and new compounds.
• NEK6 KINASE INHIBITORS USEFUL FOR THE TREATMENT OF SOLID TUMORS
  申请人：CONSIGLIO NAZIONALE DELLE RICERCHE

  公开号：US20210147395A1

  公开（公告）日：2021-05-20

  The mitotic kinases regulating the dynamics of centrosomes and the functions of the mitotic spindle are potential targets for the antitumour therapy. In the present invention some molecules with inhibitory activity on NEK6 have been identified. The present invention relates to such molecules and to the compositions including them for use as inhibitors of NEK6 in a method of treatment of tumours both in monotherapy and in combinations with other drugs.