2-(3,4-Dihydro-2H-quinolin-1-yl)-butyric acid | 80050-82-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(3,4-Dihydro-2H-quinolin-1-yl)-butyric acid
• 英文别名: 2-(3,4-dihydro-2H-quinolin-1-yl)butanoic acid
• CAS: 80050-82-4
• 化学式: C₁₃H₁₇NO₂
• 分子量: 219.283
• InChiKey: WJBIPFIIELKNQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(3,4-Dihydro-2H-quinolin-1-yl)-butyric acid ethyl ester 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以95%的产率得到2-(3,4-Dihydro-2H-quinolin-1-yl)-butyric acid
  参考文献：
  名称：

  Fungistatic action of N-(carboxyalkyl)-1,2,3,4-tetrahydroquinolines and their derivatives

  摘要：

  DOI：

  10.1007/bf00760667

文献信息

• IINA, I. G.;IVANOVA, E. V.;POTAPOV, V. M.;BOBKOVA, T. S.;ZLOCHEVSKAYA, I.+, XIM.-FARMATS. ZH., 1981, 15, N 9, 44-48
  作者：IINA, I. G.、IVANOVA, E. V.、POTAPOV, V. M.、BOBKOVA, T. S.、ZLOCHEVSKAYA, I.+

  DOI：——

  日期：——
• [EN] TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DERIVES DE TETRAHYDROQUINOLINE ET LEUR UTILISATION EN MEDECINE, PROCEDE DE PREPARATION ASSOCIE ET COMPOSITIONS PHARMACEUTIQUES CONTENANT LESDITS COMPOSES
  申请人：REDDYS LAB LTD DR

  公开号：WO2003006022A1

  公开（公告）日：2003-01-23

  The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
• Fungistatic action of N-(carboxyalkyl)-1,2,3,4-tetrahydroquinolines and their derivatives
  作者：I. G. Il'ina、E. V. Ivanova、V. M. Potapov、T. S. Bobkova、I. V. Zlochevskaya、L. N. Chekunova

  DOI：10.1007/bf00760667

  日期：1981.9