2-甲基吲哚-3-甲酰胺 | 67242-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 2-甲基吲哚-3-甲酰胺
• 英文名称: 2-methyl-1H-indole-3-carboxamide
• 英文别名: 2-Methylindol-3-carboxamid；2-methyl-indole-3-carboxylic acid amide；2-Methyl-indol-3-carbonsaeure-amid
• CAS: 67242-60-8
• 化学式: C₁₀H₁₀N₂O
• mdl: MFCD00143101
• 分子量: 174.202
• InChiKey: QKWLFJZXUBMFLU-UHFFFAOYSA-N

物化性质

• 熔点：
  225 °C
• 稳定性/保质期：
  在常温常压下稳定，应远离氧化剂。

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-dichloroacetyl-2-methylindole 在 ammonium hydroxide 作用下， 生成 2-甲基吲哚-3-甲酰胺
  参考文献：
  名称：

  Sanna, Gazzetta Chimica Italiana, 1931, vol. 61, p. 60,71

  摘要：

  DOI：

文献信息

• [EN] OXIME COMPOUNDS USEFUL AS T CELL ACTIVATORS<br/>[FR] COMPOSÉS OXIME UTILES COMME ACTIVATEURS DE LYMPHOCYTES T
  申请人：GOSSAMER BIO SERVICES INC

  公开号：WO2021258010A1

  公开（公告）日：2021-12-23

  Disclosed herein are oxime compounds having the structure of Formula (I):or a pharmaceutically acceptable salt, solvate, hydrate, isomer, tautomer, racemate, or isotope thereof, wherein R1, R2, R3, a, L, X, and Y are as defined herein. Pharmaceutical compositions comprising them, processes for preparing them and uses of them to treat or prevent diseases, disorders and conditions are also provided. The compounds are inhibitors of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ) and are useful in the treatment of diseases, disorders and conditions related to DGKα and / or DGKζ activity. In particular, the compounds are useful for treating viral infections and proliferative disorders, such as cancer.

  本文披露了具有Formula (I)结构的肟化合物：或其药用可接受的盐、溶剂化合物、水合物、异构体、互变异构体、拉氏体、或同位素，其中R1、R2、R3、a、L、X和Y如本文所定义。还提供了包括它们的药物组合物、制备它们的方法以及用途，用于治疗或预防疾病、紊乱和状况。这些化合物是二酰甘油激酶α(DGKα)和二酰甘油激酶ζ(DGKζ)的抑制剂，并且在治疗与DGKα和/或DGKζ活性相关的疾病、紊乱和状况方面是有用的。特别地，这些化合物对于治疗病毒感染和增生性疾病，如癌症，是有用的。
• MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
  申请人：CONSTELLATION PHARMACEUTICALS, INC.

  公开号：US20150376190A1

  公开（公告）日：2015-12-31

  Agents having the structural Formula (II) for modulating histone methyl modifying enzymes, compositions and uses thereof for instance as anti-cancer agents are provided herein.

  本文提供了具有结构式（II）的制剂，用于调节组蛋白甲基修饰酶，例如作为抗癌制剂的组合物和用途。
• Indole-3-carboxamide derivatives
  申请人：Yoshitomi Pharmaceutical Industries, Ltd.

  公开号：EP0144986A2

  公开（公告）日：1985-06-19

  Indole-3-carboxamide derivatives of the formula: inclusive of pharmaceutically acceptable acid addition salt and/or hydrate forms thereof, wherein R' is hydrogen, C1-4 alkyl, phenyl which may be optionally substituted by halogen on the benzene ring or phenyl-C1-4 alkyl which may be optionally substituted by halogen on the benzene ring; R2 is hydrogen or C1-4, alkyl; R3 is hydrogen, halogen, C1-4 alkyl, hydroxy or C1-4 alkoxy; R4 is hydrogen, C1-4 alkyl, C3-7 cycloalkyl, allyl or benzyl which may be optionally substituted by halogen on the benzene ring or by methyl on the α-carbon; R5 is hydrogen or C1-4 alkyl; m is 0 or 1; and n is an integer of 1 to 3, are useful as neuroleptic and anxiolytic drugs, and for the prevention and treatment of psychosomatic disturbances.

  式中的吲哚-3-甲酰胺衍生物： 包括药学上可接受的酸加成盐和/或其水合物形式，其中R'是氢、C1-4烷基、苯环上可任选被卤素取代的苯基或苯环上可任选被卤素取代的苯基-C1-4烷基；R2是氢或C1-4烷基；R3是氢、卤素、C1-4烷基、羟基或C1-4烷氧基；R4 是氢、C1-4 烷基、C3-7 环烷基、烯丙基或可被苯环上的卤素或 α 碳上的甲基任选取代的苄；R5 是氢或 C1-4 烷基；m 是 0 或 1；n 是 1 至 3 的整数。
• Modulators of methyl modifying enzymes, compositions and uses thereof
  申请人：Constellation Pharmaceuticals, Inc.

  公开号：US10016405B2

  公开（公告）日：2018-07-10

  Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

  本文提供了调节甲基修饰酶的制剂、组合物及其用途。
• MEHTA G.; DHAR D. N.; SURI S. C., SYNTHESIS, 1978, NO 5, 374-376
  作者：MEHTA G.、 DHAR D. N.、 SURI S. C.

  DOI：——

  日期：——